Naturalproductman’s Blog

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Mechanism of a Diels-Alderase Enzyme

Posted by naturalproductman on May 7, 2016

Paul Race and co-workers from the University of Bristol have reported in JACS on the details of how an enzyme catalyzes a Diels-Alder reaction using crystal structures and enzyme assays. The enzyme is called spirotetronate cyclase AbyU and is key in forming the macrocyclic structure of abyssomicin C.


JACS paper


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