Naturalproductman’s Blog

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Mechanism of hexadehydro Diels Alder

Posted by naturalproductman on June 16, 2016

Thomas Hoye and co-workers reported in JACS on a substituent effect on the rate of the hexadehydro-Diels Alder reaction. Unlike the regular Diels-Alder reaction, electron-withdrawing groups slowed the reaction down suggesting a step-wise diradical mechanism as opposed to a concerted mechanism.

 

JACS paper

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