Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for November, 2017

First paper published

Posted by naturalproductman on November 6, 2017

Francis Yoshimoto and co-workers at the University of Texas at San Antonio report in the journal, Steroids, on the synthesis of a neurosteroid produced in the brains, 7alpha-hydroxypregnenolone, through an allylic C7-oxidation reaction. The oxidation was performed through either a C7-oxidation through CrO3 in the presence of 3,5-dimethylpyrazole followed by a stereoselective reduction or a regioselective and stereoselective allylic benzoyloxylation using CuBr and tert-butylperoxy benzoate.

STEROIDS FKY

Steroids paper

Advertisements

Posted in C-H activation, Stereochemistry, Steroids, Total Synthesis | Leave a Comment »