Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for November, 2018

The Synthesis of 12alpha-Hydroxy Steroids

Posted by naturalproductman on November 3, 2018

Francis Yoshimoto and co-workers at the University of Texas at San Antonio reported in Steroids on the synthesis of 12alpha-hydroxy steroid derivatives to biochemically characterize P450 8B1, the enzyme implicated in cardiovascular health and obesity. Both 7-keto DHEA and 12alpha-hydroxy 7-keto DHEA had antagonistic properties towards the NMDA receptor.

Screen Shot 2018-11-03 at 3.27.25 PM

 

Steroids paper

Posted in C-H activation, Stereochemistry, Steroids, Total Synthesis | Leave a Comment »