Naturalproductman’s Blog

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Archive for the ‘Acetogenins’ Category

Inhibition of COX-2 gene expression

Posted by naturalproductman on April 20, 2012

Wei-Chiao Chang and co-workers from Kaohsiung University in Taiwan have reported in JNP on the inhibition of COX-2 gene expression by isodesacetyluvaricin.


JNP paper


Posted in Acetogenins, Cancer | Leave a Comment »

Cytotoxic acetogenins

Posted by naturalproductman on November 10, 2011

Xiang Li and co-workers from Nanjing University of Chinese Medicine have isolated some bistetrahydrofurans.

bis tetrahydrofuran

JNP paper

Posted in Acetogenins, Cancer, Tetrahydrofuran | Leave a Comment »


Posted by naturalproductman on April 28, 2010

Yu-Dong Zhou and co-workers from the University of Mississippi have recently reported in the Journal of Natural Products on the isolation of some tetrahydrofuran containing compounds 10-hydroxyglaucanetin, annonacin, and annonacin A, which inhibited hypoxia-induced HIF-1 activation at IC50 values of 12 nM, 13 nM, and 31 nM.

paw paw crude extract

JNP paper

Posted in Acetogenins, Tetrahydrofuran | 1 Comment »