Naturalproductman’s Blog

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Archive for the ‘Alkaloids’ Category

Dragmacidin D synthesis

Posted by naturalproductman on July 1, 2015

I first was introduced to dragmacidins when I started reading work about Stoltz’s group, which was published in JACS, but I didn’t know that Zakarian’s group has also been working on its synthesis and published it in ACIE.

dragmacidin

ACIE paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Alzmaphorazine B synthesis

Posted by naturalproductman on June 6, 2015

Christopher Vanderwal and colleague have reported in JACS on a synthesis of alzmaphorazine B.

alkaloid

JACS paper

Posted in Alkaloids, Biosynthesis, Total Synthesis | Leave a Comment »

Nodulisporic acid D synthesis

Posted by naturalproductman on June 6, 2015

Amos Smith and co-workers have reported in JACS on the synthesis of nodulisporic acid D.

alkaloid

JACS paper

Posted in Alkaloids, Total Synthesis, Transition Metal | Leave a Comment »

Sarain A synthesis

Posted by naturalproductman on May 12, 2015

Tohru Fukuyama and co-workers at Nagoya University and the University of Tokyo have reported in ACIE on a formal synthesis of sarain A.

sarain

ACIE paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Gelsemoxonine synthesis

Posted by naturalproductman on May 4, 2015

Erick Carreira and colleague have reported in JACS on the synthesis of gelsemoxonine.

alkaloid

JACS paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Serpentine synthesis

Posted by naturalproductman on May 2, 2015

Karl Scheidt and co-workers have reported in ACIE on the synthesis of alstonine and serpentine through cooperative catalysis.
heteroyohimbine
ACIE paper

Posted in Alkaloids, Cooperative Catalysis, Methodology, Total Synthesis | Leave a Comment »

Mycoleptodiscin A synthesis

Posted by naturalproductman on April 26, 2015

Ang Li and co-workers from SIOC have reported in ACIE on the synthesis of mycoleptodiscin A.

mycoleptodiscin
ACIE paper

Posted in Alkaloids, Steroids, Total Synthesis | Leave a Comment »

Eudistidine A

Posted by naturalproductman on April 20, 2015

The NCI does some nice work with natural products. Kirk Gustafson and co-workers at Bethesda have reported in JACS on some new natural products that block the interaction between p300 and HIF1alpha.

70

JACS paper

Posted in Alkaloids, Protein-Protein Interaction, Proteins, Total Synthesis | Leave a Comment »

Galanthamine and lycoramine syntheses

Posted by naturalproductman on April 12, 2015

Yanxing Jia and co-workers at Peking University have reported in ACIE on the synthesis galanthamine and lycoramine.
galanthamine

ACIE paper

Posted in Alkaloids, Asymmetric, Methodology, Total Synthesis, Transition Metal | Leave a Comment »

Paspaline synthesis

Posted by naturalproductman on April 12, 2015

Jeffrey Johnson and colleague at UNC have reported in JACS on the synthesis of paspaline.
paspaline

JACS paper

Posted in Alkaloids, Cascade Reactions, Total Synthesis | Leave a Comment »

 
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