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Archive for the ‘Alkaloids’ Category

Luteoalbusin synthesis

Posted by naturalproductman on August 27, 2015

Mohammad Movassaghi and co-workers have reported in Organic Letters on the syntheses of
polythio

OL paper

Posted in Alkaloids, Polythio Compounds, Total Synthesis | Leave a Comment »

Bicyclomycin formal synthesis

Posted by naturalproductman on August 26, 2015

Ullrich Jahn and co-workers from the Academy of the Sciences of the Czech Republic reported in ACIE on a formal synthesis of bicyclomycin.
radical
ACIE paper

Posted in Alkaloids, Cascade Reactions, Methodology, Total Synthesis | Leave a Comment »

Diels-Alder approach to galbulimima alkaloids

Posted by naturalproductman on August 25, 2015

Here’s a paper related to the galbulimima alkaloids, which were made famous by Lewis Mander’s group. Regan Thomson and co-workers report in JACS on the synthesis of galbulimima alkaloids. A nice collaboration with DFT calculations from Dean Tantillo’s group shows the orbital interactions in the transition state structures of the Diels-Alder reactions.
galbulimima

JACS paper

Posted in Alkaloids, DFT, Diels-Alder, Methodology, Total Synthesis | Leave a Comment »

Mycothiazole synthesis

Posted by naturalproductman on August 21, 2015

Karl Hale and colleague at the Queen’s University Belfast have reported in Organic Letters on the synthesis of mycothiazole.

mycothiazole

OL paper

Posted in Alkaloids, Methodology, Structural Reassignment, Thiazoles, Total Synthesis | Leave a Comment »

Secu’amamine A synthesis

Posted by naturalproductman on August 21, 2015

Amos Smith and colleague have reported in Organic Letters on the synthesis of secu’amamine A.
secu'amamine A
OL paper

Posted in Alkaloids, Methodology, Multi-Component Coupling, Total Synthesis | Leave a Comment »

Pseudotabersonine via double ring closing metathesis

Posted by naturalproductman on August 19, 2015

Stephen Martin and co-workers reported in Tetrahedron on the synthesis of pseudotabersonine using a double ring closing metathesis approach.

double RCM

Tetrahedron paper

Posted in Alkaloids, Metathesis, Methodology, Ruthenium, Total Synthesis, Transition Metal | Leave a Comment »

ent-Ketorfanol synthesis

Posted by naturalproductman on August 18, 2015

Jonathan Ellman and co-workers have reported in ACIE on the synthesis of ent-ketorfanol.

alkaloid

ACIE paper

Posted in Alkaloids, Rhodium, Total Synthesis, Transition Metal | Leave a Comment »

Oridamycin synthesis

Posted by naturalproductman on July 22, 2015

Another solo performance from Danishefsky’s lab published by Adam Trotta.

OL paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Penibruguieramine A synthesis

Posted by naturalproductman on July 22, 2015

Sanghee Kim and co-workers from Seoul National University have reported in ACIE on the synthesis of penibruguieramine A.

alkaloid

ACIE paper

Posted in Alkaloids, Asymmetric, Kinetic resolution, Methodology, Total Synthesis | Leave a Comment »

Hosieine A synthesis

Posted by naturalproductman on July 22, 2015

Ran Hong and co-workers at SIOC have reported in ACIE on the synthesis of hosieine A. The pyridone moiety reminds of lyconadin.

alkaloid

ACIE paper

Posted in Alkaloids, Cascade Reactions, Methodology, Total Synthesis | Leave a Comment »

 
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