Naturalproductman’s Blog

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Archive for the ‘Alkynes’ Category

Callyspongiolide synthesis

Posted by naturalproductman on May 29, 2016

Tao Ye and co-workers from Peking University have reported in JACS on the synthesis of callyspongiolide.


JACS paper

Posted in Alkynes, Macrolides, Polyketides, Total Synthesis | Leave a Comment »

Markovnikov addition – terminal alkynes to ketones

Posted by naturalproductman on April 19, 2016

Chao-Jun Li and co-workers from McGill University reported in Organic Letters on a useful transformation that converts a terminal alkyne to a ketone using trifluoroethanol as the solvent and triflic acid.


OL paper

Posted in Alkynes, Cascade Reactions, Methodology | Leave a Comment »

Unciaphenol – Bergman cyclization product of uncialamycin

Posted by naturalproductman on October 16, 2015

Raymond Anderson and co-workers at the University of British Columbia report in Organic Letters on unciaphenol, which has anti-HIV activity.


OL paper

Posted in Alkynes, Cascade Reactions, Diseases, HIV, Named Reactions, Polyketides | Leave a Comment »

Mollenynes B-E

Posted by naturalproductman on September 25, 2015

Tadeusz Molinski and co-workers have reported in JACS on the isolation and characterization of mollenynes B-E.
JACS paper

Posted in Alkynes, Computational, DFT, Halogenated, New Techniques, NMR, Peptides, Polyenes, Stereochemistry | Leave a Comment »