Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Antibiotics’ Category

Towards naphthocyclinones

Posted by naturalproductman on July 1, 2015

Keisuke Suzuki and co-workers at the Tokyo Institute of Technology have reported in ACIE on their strategy towards Naphthocyclinones.

polyketide

ACIE paper

Posted in Antibiotics, Dimer, Polyketides | Leave a Comment »

Nanocystin A

Posted by naturalproductman on June 6, 2015

Here’re some macrocycles reported in ACIE.
nanocystin A

ACIE paper

Posted in Antibiotics, Macrocycles | Leave a Comment »

Rearrange to more complexity

Posted by naturalproductman on July 27, 2014

Paul Hergenrother and co-workers from UIUC have reported in ACIE on an interesting rearrangement to form fenestrane ring systems.

cyclopropane

ACIE paper

Posted in Antibiotics, Cascade Reactions, Mechanistic, Methodology | Leave a Comment »

Agelamadins

Posted by naturalproductman on July 15, 2014

More oroidin dimers were isolated – I was reminded of palau’amine.

agelamadins

OL paper

Posted in Alkaloids, Antibiotics | Leave a Comment »

Aspergillomarasmine A

Posted by naturalproductman on June 28, 2014

Gerald Wright and co-workers from McMaster University in Canada have reported in Nature on aspergillomarasmine A being a good inhibitor for the New Dehli Metallo beta-lactamase 1 (NDM-1) enzyme.

 

Nature paper

Posted in Amino Acids, Antibiotics, Diseases | 1 Comment »

Baulamycins

Posted by naturalproductman on January 17, 2014

David Sherman and co-workers found some new natural products with anti-biotic activities (IC50s ranging from low to high micromolar range) and reported this in JACS.
baulamycins

 

JACS paper

Posted in Antibiotics, Polyketides | Leave a Comment »

BE-43472B synthesis

Posted by naturalproductman on May 17, 2013

Keisuke Suzuki and co-workers at Tokyo Institute of Technology have reported in ACIE on the synthesis of

antibiotic

ACIE paper

Posted in Antibiotics, Methodology, Total Synthesis | Leave a Comment »

Pactamycin synthesis

Posted by naturalproductman on April 12, 2013

Jeffrey Johnson and co-workers at UNC have reported in Science on the synthesis of pactamycin.

 

Science paper

Posted in Antibiotics, Total Synthesis | Leave a Comment »

Tetarimycin A

Posted by naturalproductman on November 27, 2012

Sean Brady and co-workers from Rockefeller University have reported in JACS on the isolation of tetarimycin A, which had a MIC (minimum inhibitory concentration) of 1.5 micrograms/mL against S. aureus 6538P.

antibiotic

JACS paper

Posted in Antibiotics, Chemical Biology, Polyketides | Leave a Comment »

Obtusinone A

Posted by naturalproductman on December 11, 2011

Chatchanok Karalai and co-workers at Prince of Songkla University have reported in Tetrahedron on an diterpene with anti-inflammatory properties.

obtusinone

Tetrahedron paper

Posted in Anti-inflammatory, Antibiotics, Diterpene | Leave a Comment »

 
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