Naturalproductman’s Blog

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Archive for the ‘Antibiotics’ Category

Darwinolide

Posted by naturalproductman on May 30, 2016

Bill Baker and co-workers at the University of South Florida have reported in Organic Letters on the isolation of darwinolide from an antarctic sponge that inhibited methicillin-resistant S. aureus biofilm formation.

 

OL paper

Posted in Antibiotics, Diterpene, Lactones | Leave a Comment »

Vancomycin derivative

Posted by naturalproductman on May 29, 2016

Here’s a report on a vancomycin derivative with a pyrophosphate binding group reported by Jayanta Haldar and co-workers at Jawaharlal Nehru Centre for Advanced Scientific Research.

 

ACIE paper

Posted in Antibiotics, Peptides, Unnatural Products | Leave a Comment »

Roseoflavin biosynthesis

Posted by naturalproductman on April 11, 2016

Matthias Mack and co-workers from Mannheim University have reported in ACIE on the identification of an enzyme found in the biosynthesis of roseoflavin.

 

ACIE paper

Posted in Alkaloids, Antibiotics, Biosynthesis | Leave a Comment »

Biochemometric analysis ~ natural products (altersetin)

Posted by naturalproductman on February 9, 2016

Nadja Cech and co-workers at UNC Greensboro have reported in the Journal of Natural Products on the isolation of altersetin, an antibacterial alkaloid.

 

JNP paper

Posted in Alkaloids, Antibiotics, New Techniques | Leave a Comment »

Towards naphthocyclinones

Posted by naturalproductman on July 1, 2015

Keisuke Suzuki and co-workers at the Tokyo Institute of Technology have reported in ACIE on their strategy towards Naphthocyclinones.

polyketide

ACIE paper

Posted in Antibiotics, Dimer, Polyketides | Leave a Comment »

Nanocystin A

Posted by naturalproductman on June 6, 2015

Here’re some macrocycles reported in ACIE.
nanocystin A

ACIE paper

Posted in Antibiotics, Macrocycles | Leave a Comment »

Rearrange to more complexity

Posted by naturalproductman on July 27, 2014

Paul Hergenrother and co-workers from UIUC have reported in ACIE on an interesting rearrangement to form fenestrane ring systems.

cyclopropane

ACIE paper

Posted in Antibiotics, Cascade Reactions, Mechanistic, Methodology | Leave a Comment »

Agelamadins

Posted by naturalproductman on July 15, 2014

More oroidin dimers were isolated – I was reminded of palau’amine.

agelamadins

OL paper

Posted in Alkaloids, Antibiotics | Leave a Comment »

Aspergillomarasmine A

Posted by naturalproductman on June 28, 2014

Gerald Wright and co-workers from McMaster University in Canada have reported in Nature on aspergillomarasmine A being a good inhibitor for the New Dehli Metallo beta-lactamase 1 (NDM-1) enzyme.

 

Nature paper

Posted in Amino Acids, Antibiotics, Diseases | 1 Comment »

Baulamycins

Posted by naturalproductman on January 17, 2014

David Sherman and co-workers found some new natural products with anti-biotic activities (IC50s ranging from low to high micromolar range) and reported this in JACS.
baulamycins

 

JACS paper

Posted in Antibiotics, Polyketides | Leave a Comment »