Naturalproductman’s Blog

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Archive for the ‘C2-Symmetric’ Category

No that’s not BINAP

Posted by naturalproductman on April 25, 2012

N. P. Dhammika Nanayakkara and co-workers from the University of Mississippi have reported in JNP on the isolation of some compounds that look like BINAP.

antiprotozoal

JNP paper

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Posted in Aromatic, C2-Symmetric | Leave a Comment »

Rhizopodin synthesis

Posted by naturalproductman on April 24, 2012

Dirk Menche and co-workers from Universität Heidelberg have reported in ACIE on the synthesis of rhizopodin.

rhizopodin

ACIE paper

Posted in C2-Symmetric, Macrolides, Methodology, Oxazoles, Total Synthesis | Leave a Comment »

Mycocyclosin synthesis

Posted by naturalproductman on April 21, 2012

Craig Hutton and co-workers from the University of Melbourne have reported in Organic Letters on the synthesis of mycocyclosin.

mycocyclosin

OL paper

Posted in Alkaloids, C2-Symmetric, Methodology, Total Synthesis | Leave a Comment »

Spirocycle formation

Posted by naturalproductman on February 17, 2012

Trevor Rainey and colleague at Montana State University have reported in JACS on a palladium catalyzed cyclobutanol ring expansion to form a spirocycle.

palladium

JACS paper

Posted in Asymmetric, C2-Symmetric, Cascade Reactions, Methodology, Palladium, Transition Metal | Leave a Comment »

Viriditoxin

Posted by naturalproductman on January 24, 2012

Jared Shaw and co-workers at UC Davis have reported in Synthesis on their approach towards viriditoxin.

biaryl

Synthesis paper

Posted in Aromatic, C2-Symmetric, Dimer, Metathesis, Methodology, Total Synthesis | Leave a Comment »

Desymmetrizing a meso compound

Posted by naturalproductman on November 12, 2011

Pauline Chiu and co-workers from the University of Hong Kong have published in Tetrahedron Letters on a desymmetrization of a meso compound to form a five membered ring with modest ee (50% ee).

50%

TL paper

Posted in C2-Symmetric, Carbene, Copper, Desymmetrization, Methodology, Transition Metal | Leave a Comment »

Alpha-arylation

Posted by naturalproductman on August 19, 2011

Matthew Gaunt and co-workers at the University of Cambridge and David Macmillan and co-workers at Princeton have independently published in JACS on hypervalent iodide mediated alpha-arylations of amides.

hypervalent

JACS paper 1

hypervalent iodide

JACS paper 2

Posted in Asymmetric, C2-Symmetric, Copper, Hypervalent Iodine, Methodology, Transition Metal | Leave a Comment »

Alstoscholarine Syntheses

Posted by naturalproductman on April 3, 2011

Jieping Zhu and co-workers at CNRS have reported in ACIEE on a synthesis of alstoscholarine – what a scholarly piece of work.

alstoscholarine

ACIEE paper

Posted in Alkaloids, C2-Symmetric, Cascade Reactions, Methodology, Named Reactions, Pictet-Spengler, Takeda olefination | Leave a Comment »

Viriditoxin A Synthesis

Posted by naturalproductman on March 18, 2011

Jared Shaw and co-workers at UC Davis have reported in ACIEE on the total synthesis of viriditoxin A a C2 symmetric molecule.

viriditoxin

ACIEE paper

Posted in Aromatic, C2-Symmetric, Coumarins, Methodology | Leave a Comment »

Umpolung 1,3-dipolar cycloaddition

Posted by naturalproductman on March 9, 2011

Keiji Maruoka and co-workers have published in ACIEE on a 1,3-dipolar cycloaddition with azomethine ylides.

1,3 dipolar

ACIEE paper

Posted in C2-Symmetric, Cascade Reactions, Cycloaddition, Methodology, Organocatalytic, Pericyclic reactions | Leave a Comment »