Plakinamines N and O

Kirk Gustafson and co-workers from the NCI have reported in JNP on the isolation of plakinamines N and O.

JNP paper

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Mollipilins A and B

Teigo Asai and co-workers from Tohoku University have reported in Organic Letters on the isolation of mollipilins A and B, which had moderate cytotoxicity against human colon cancer cells at 1.8 and 3.7 micomolar IC50 values.

OL paper

Halichoblelides B and C

Takeshi Yamada and co-workers at Osaka University of Pharmaceutical Sciences have reported in Tetrahedron on the isolation of some cytotoxic natural products, halichoblelides B and C.

TL paper

Hamamelitannin

Marta Cascante and co-workers at the Universitat Barcelona have reported in Journal of Natural Products on the isolation of hamamelitannin, which had anti-colon cancer activity.

JNP paper

Mollenyne A

Tadeusz Molinski and colleague at UCSD have reported in Organic Letters on the isolation of mollenyne A which had an IC50 value of 1.3 micrograms/mL against human colon cancer cell lines (HCT-116).

OL paper

Premnalatifolin A

Suresh Babu and co-workers at IICT have reported in Tetrahedron Letters on the isolation of a dimeric diterpene dubbed premnalatifolin A from an Indian medicinal plant, Premna latifolia.  This compound had IC₅₀ values of 12.15 and 1.11 μg/mL against HT-29 and MCF-7 cell lines, respectively.

TL paper

PM050511

Fernando de la Calle and co-workers at PharmaMar SAU in Spain have reported in JNP on the isolation of some actinopyranones that had anti-cancer activities (PM060431 had 0.38 micromolar GI50 against HT29).

JNP paper

Nocardioazines

Robert Capon and co-workers at the University of Queensland have reported in Organic Letters on the isolation of prenylated diketopiperazines.  Nocardioazine A had an IC50 of 59 micromolar against colon cancer cell lines (SW620).

OL paper

Chabamides from Piper chaba Hunter

Madhusudana Rao and co-workers at IICT have reported in Tetrahedron on the isolation of chabamides.  Chabamide G had an IC50 of 0.018 micrograms/mL against COLO-205 cancer cell line.

Tetrahedron paper

Franklinolides A-C

Robert Capon and co-workers have published in ACIEE on the isolation of three new polyketide phosphodiesters, franklinolides A-C.  Franklinolide A had an IC50 value of 1.7 micromolar against the HT29 (colorectal adenocarcinoma) cancer cell lines.

ACIEE paper