Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘leukemia’ Category

Rossinone Synthesis

Posted by naturalproductman on November 9, 2010

Yefeng Tang and co-workers from Tsinghua University have published in Organic Letters on the synthesis of rossinone with the key reaction being an intramolecular vinyl quinone Diels-Alder reaction.  This molecule has an IC50 value of 84 nM against p-388 murine leukemia cell lines.

Diels Alder

 

OL paper

Posted in Cancer, Cascade Reactions, Diels-Alder, leukemia, Methodology, Named Reactions, Ring forming | Leave a Comment »

Lagunamide A

Posted by naturalproductman on October 14, 2010

Lik Tong Tan and co-workers at Nanyang Technological University in Singapore have published in the Journal of Natural Products on the isolation of a peptide that had anti-malarial and anti-cancer properties with IC50 values of 0.19 micromolar against Plasmodium falciporum and 6.4 nM against P388 murine leukemia cell lines.

antimalarial

 

JNP paper

Posted in Cancer, Diseases, leukemia, Malaria, Peptides | Leave a Comment »