Naturalproductman’s Blog

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Archive for the ‘prostate’ Category


Posted by naturalproductman on April 19, 2012

Satoshi Endo and co-workers from Gifu Pharmaceutical University have reported in JNP on the isolation of baccharin a 17-beta-hydroxysteroid dehydrogenase inhibitor.


JNP paper

Posted in Aromatic, breast, Cancer, prostate | Leave a Comment »

Arabilin synthesis

Posted by naturalproductman on December 2, 2011

Kathlyn Parker and colleague have reported in JACS on a synthesis of arabilin, an androgen receptor antagonist that can potentially treat prostate cancer (IC50 of 11 micromolar towards AR).  A 1,7-hydride shift occured in their key Stille coupling to afford the correct isomer.


JACS paper

Posted in Cancer, Cascade Reactions, cross coupling, Hydride Shift, Methodology, prostate, Protein Targets, Proteins, Receptors, Stille, Transition Metal | Leave a Comment »


Posted by naturalproductman on August 10, 2011

Thomas Simmet and co-workers from Ulm University have reported in the Journal of Natural Products on the isolation of (8R)-3β,8-Dihydroxypolypoda-13E,17E,21-triene from the oleogum resin of P. lentiscus.  This compound had inhibitory activity against androgen-insensitive prostate cancers (~10 micromolar).


JNP paper

Posted in Cancer, prostate, Triterpenoids, Trophy Targets | Leave a Comment »

Archazolids E and F

Posted by naturalproductman on April 27, 2011

Dirk Mensche and colleagues at Ruprecht-Karls-Universitat Heidelberg in Germany have reported in the Journal of Natural Products on the isolation of archazolids E and F.  Archazolid F had an IC50 of 0.131 nM against MCF7 breast adenocarcinoma cell lines.


JNP paper

Posted in breast, Cancer, Polyketides, prostate | Leave a Comment »

Sterol Glycosides

Posted by naturalproductman on December 7, 2010

Julia Kubanek and co-workers at Georgia Institute of Technology have published in Bioorganic and Medicinal Chemistry on the isolation of sterol glycosides, 19-O-β-d-glucopyranosyl-19-hydroxy-cholest-4-en-3-one (1) and 19-O-β-d-N-acetyl-2-aminoglucopyranosyl-19-hydroxy-cholest-4-en-3-one (2), which were collected from the Fijian red alga Peyssonnelia sp.  and had biological activity against human breast cancer cell lines MDA-MB-468 with IC50 = 0.71 and 0.86 μM, respectively.

sterol glycosides


BMC paper

Posted in breast, Cancer, Chemical Biology, Glycosides, prostate, Steroids | Leave a Comment »


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