Naturalproductman’s Blog

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Archive for the ‘Chemical Biology’ Category

CO-Releasing molecules (CORMs)

Posted by naturalproductman on June 7, 2015

Hans-Günther Schmalz and co-workers from Universität zu Köln have reported in ACIE on some small molecules that release carbon monoxide upon reacting with protease.

CO

ACIE paper

Posted in Chemical Biology, Unnatural Products | Leave a Comment »

Englerin A activates TRPC4 and TRPC5

Posted by naturalproductman on February 23, 2015

Herbert Waldmann and co-workers at Max-Planck-Institut fur Molekulare Physiologie have reported in ACIE on the target of englerin A. This report is very interesting. When I think of TRPC channels (Transient receptor potential canonical channels), I usually think of our taste buds and how the different electrophiles activate different tastes (bitterness, etc). I guess this calcium influx kills the cancer cells according to the authors. And some how this is all happening selectively for renal cancer cells and not the other kind of cancer cells.
englerin A

ACIE paper

Posted in Chemical Biology, Protein Targets, Sesquiterpenes | Leave a Comment »

Tetracycline analogs

Posted by naturalproductman on February 22, 2015

Hrvoje Petkovic and co-workers at University of Ljubljana have reported in ACIE on a biosynthetic engineering approach to produce new tetracycline compounds.

tetracycline

ACIE paper

Posted in Biosynthesis, Chemical Biology, Polyketides, Tetracycline | Leave a Comment »

Looks like bromophakellin

Posted by naturalproductman on January 17, 2015

Michael Groll and co-workers at Michigan State have reported in ACIE on the target of of some indolo-phakellin natural products (proteasome).

phakellin

ACIE paper

Posted in Alkaloids, Chemical Biology, Indoles | Leave a Comment »

Combining chemical and enzymatic synthesis

Posted by naturalproductman on November 29, 2014

Kevin Reynolds and co-workers from Portland State University have reported in JOC on the synthesis of premarineosin analogs using a chemo-enzymatic approach.

marineosin

JOC paper

Posted in Alkaloids, Chemical Biology, Enzymatic, Methodology, Total Synthesis, Unnatural Products | 1 Comment »

Apoptolidins localize in mitochondria

Posted by naturalproductman on November 28, 2014

Gary Sulikowski and co-workers at Vanderbilt University have reported in ACIE on the use of some fluorescent probe versions of apoptolidin natural products and determined that the natural product localizes in the mitochondria of cancer cells.

mitochondria

ACIE paper

Posted in Cancer, Chemical Biology, lung, Polyketides | Leave a Comment »

Monodihydrosterculin

Posted by naturalproductman on November 27, 2014

Ehud Landau and co-workers at the University of Zurich have reported in ACIE on the use of a cyclopropane-containing lipid to crystallize membrane proteins.
MDS

ACIE paper

Posted in Chemical Biology, Lipids, New Setups, Unnatural Products | Leave a Comment »

Imaging bacterial infections

Posted by naturalproductman on November 10, 2014

Niren Murthy and co-workers from UC Berkeley have reported in ACIE on a way to image bacterial infections.

bacteria

ACIE paper

Posted in Chemical Biology, Imaging, Methodology | Leave a Comment »

Spinosyn A, chemoenzymatically

Posted by naturalproductman on October 11, 2014

Hung-Wen Liu and co-workers from UT Austin have reported in ACIE on the chemoenzymatic synthesis of spinosyn A.

spinosyn A

 

ACIE paper

Posted in Chemical Biology, Chemoenzymatic | Leave a Comment »

PPARγ is the target of ainsliatrimer A

Posted by naturalproductman on October 4, 2014

Xiaoguang Lei and co-workers from NIBS have reported in ACIE on the target of ainsliatrimer A, which was determined to be PPARγ.

ainsliatrimer A

ACIE paper

Posted in Cancer, Chemical Biology | Leave a Comment »

 
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