Naturalproductman’s Blog

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Archive for the ‘Chemical Biology’ Category

Cyclopropenones – a chemical biology tool

Posted by naturalproductman on August 7, 2015

Jennifer Prescher and colleague at UC Irvine have reported in JACS on the potential for using cyclopropenones to conjugate proteins.

amine

JACS paper

Posted in Cascade Reactions, Chemical Biology, New Setups | Leave a Comment »

Molecular prosthetics

Posted by naturalproductman on August 7, 2015

Martin Burke’s group is making use of their small molecules that they’re synthesizing.
prosthetic
JACS paper

Posted in Chemical Biology, Macrolides, Methodology, Polyenes, Polyketides | Leave a Comment »

Nannocystin A

Posted by naturalproductman on July 17, 2015

Dominic Hoepfner and co-workers from Novartis have reported in ACIE on nannocystin A, which had similar binding properties with didemin B on EF-1alpha (elongation factor 1 inhibitor).

nannocystin A

ACIE paper

Mark Brönstrup and co-workers at Helmholtz Zentrum für Infektionsforschung also reported on the isolation of this small molecule. I wonder if there’s a relationship between the two studies.

ACIE paper

the novartis paper states that their study parallels the work in helmholtz. I guess the two studies just coincidentally resulted in the isolation of the same compound.

Posted in Biosynthesis, Cancer, Chemical Biology, Macrocycles, Macrolides, Peptides | Leave a Comment »

Staphyloferrin B synthesis

Posted by naturalproductman on July 11, 2015

Elizabeth Nolan and co-workers from MIT have reported in JACS on the synthesis of staphyloferrin B, an iron chelating natural product found in bacteria.

iron

JACS paper

Posted in Chemical Biology, Peptides, Total Synthesis | Leave a Comment »

CO-Releasing molecules (CORMs)

Posted by naturalproductman on June 7, 2015

Hans-Günther Schmalz and co-workers from Universität zu Köln have reported in ACIE on some small molecules that release carbon monoxide upon reacting with protease.

CO

ACIE paper

Posted in Chemical Biology, Unnatural Products | Leave a Comment »

Englerin A activates TRPC4 and TRPC5

Posted by naturalproductman on February 23, 2015

Herbert Waldmann and co-workers at Max-Planck-Institut fur Molekulare Physiologie have reported in ACIE on the target of englerin A. This report is very interesting. When I think of TRPC channels (Transient receptor potential canonical channels), I usually think of our taste buds and how the different electrophiles activate different tastes (bitterness, etc). I guess this calcium influx kills the cancer cells according to the authors. And some how this is all happening selectively for renal cancer cells and not the other kind of cancer cells.
englerin A

ACIE paper

Posted in Chemical Biology, Protein Targets, Sesquiterpenes | Leave a Comment »

Tetracycline analogs

Posted by naturalproductman on February 22, 2015

Hrvoje Petkovic and co-workers at University of Ljubljana have reported in ACIE on a biosynthetic engineering approach to produce new tetracycline compounds.

tetracycline

ACIE paper

Posted in Biosynthesis, Chemical Biology, Polyketides, Tetracycline | Leave a Comment »

Looks like bromophakellin

Posted by naturalproductman on January 17, 2015

Michael Groll and co-workers at Michigan State have reported in ACIE on the target of of some indolo-phakellin natural products (proteasome).

phakellin

ACIE paper

Posted in Alkaloids, Chemical Biology, Indoles | Leave a Comment »

Combining chemical and enzymatic synthesis

Posted by naturalproductman on November 29, 2014

Kevin Reynolds and co-workers from Portland State University have reported in JOC on the synthesis of premarineosin analogs using a chemo-enzymatic approach.

marineosin

JOC paper

Posted in Alkaloids, Chemical Biology, Enzymatic, Methodology, Total Synthesis, Unnatural Products | 1 Comment »

Apoptolidins localize in mitochondria

Posted by naturalproductman on November 28, 2014

Gary Sulikowski and co-workers at Vanderbilt University have reported in ACIE on the use of some fluorescent probe versions of apoptolidin natural products and determined that the natural product localizes in the mitochondria of cancer cells.

mitochondria

ACIE paper

Posted in Cancer, Chemical Biology, lung, Polyketides | Leave a Comment »

 
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