Herbert Waldmann and co-workers at Max-Planck-Institut fur Molekulare Physiologie have reported in ACIE on the target of englerin A.
Archive for the ‘Chemical Biology’ Category
Englerin A inhibits TRPC4 and TRPC5
Posted by naturalproductman on February 23, 2015
Posted in Chemical Biology, Protein Targets, Sesquiterpenes | Leave a Comment »
Tetracycline analogs
Posted by naturalproductman on February 22, 2015
Hrvoje Petkovic and co-workers at University of Ljubljana have reported in ACIE on a biosynthetic engineering approach to produce new tetracycline compounds.
Posted in Biosynthesis, Chemical Biology, Polyketides, Tetracycline | Leave a Comment »
Looks like bromophakellin
Posted by naturalproductman on January 17, 2015
Michael Groll and co-workers at Michigan State have reported in ACIE on the target of of some indolo-phakellin natural products (proteasome).
Posted in Alkaloids, Chemical Biology, Indoles | Leave a Comment »
Combining chemical and enzymatic synthesis
Posted by naturalproductman on November 29, 2014
Kevin Reynolds and co-workers from Portland State University have reported in JOC on the synthesis of premarineosin analogs using a chemo-enzymatic approach.
Posted in Alkaloids, Chemical Biology, Enzymatic, Methodology, Total Synthesis, Unnatural Products | 1 Comment »
Apoptolidins localize in mitochondria
Posted by naturalproductman on November 28, 2014
Gary Sulikowski and co-workers at Vanderbilt University have reported in ACIE on the use of some fluorescent probe versions of apoptolidin natural products and determined that the natural product localizes in the mitochondria of cancer cells.
Posted in Cancer, Chemical Biology, lung, Polyketides | Leave a Comment »
Monodihydrosterculin
Posted by naturalproductman on November 27, 2014
Ehud Landau and co-workers at the University of Zurich have reported in ACIE on the use of a cyclopropane-containing lipid to crystallize membrane proteins.
Posted in Chemical Biology, Lipids, New Setups, Unnatural Products | Leave a Comment »
Imaging bacterial infections
Posted by naturalproductman on November 10, 2014
Niren Murthy and co-workers from UC Berkeley have reported in ACIE on a way to image bacterial infections.
Posted in Chemical Biology, Imaging, Methodology | Leave a Comment »
Spinosyn A, chemoenzymatically
Posted by naturalproductman on October 11, 2014
Hung-Wen Liu and co-workers from UT Austin have reported in ACIE on the chemoenzymatic synthesis of spinosyn A.
Posted in Chemical Biology, Chemoenzymatic | Leave a Comment »
PPARγ is the target of ainsliatrimer A
Posted by naturalproductman on October 4, 2014
Xiaoguang Lei and co-workers from NIBS have reported in ACIE on the target of ainsliatrimer A, which was determined to be PPARγ.
Posted in Cancer, Chemical Biology | Leave a Comment »
Cholesterol analog to probe SHH protein
Posted by naturalproductman on August 20, 2014
Edward Tate and co-workers from Imperial College in London have reported in Chemical Science on a cholesterol analog that allowed them to probe the sonic hedgehog protein, a peptide that undergoes post-translational modification with cholesterol.
Posted in Chemical Biology, Unnatural Products | Leave a Comment »
