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Archive for the ‘Chemoenzymatic’ Category

Patent review – biocatalysts

Posted by naturalproductman on April 8, 2016

David Hughes at Cidara Therapeutics reported in ORPD on a patent literature search pertaining the use of biocatalysts to effect chemical transformations. He covers some P450 mediated cyclopropanation, reductive amination, Diels-Alder (artificial enzyme), nitrilase (conversion of nitrile to carboxylic acid)  reactions all catalyzed by enzymes.

 

ORPD paper

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Posted in Biocatalysis, Chemical Biology, Chemoenzymatic, Enzymatic | Leave a Comment »

Spinosyn A, chemoenzymatically

Posted by naturalproductman on October 11, 2014

Hung-Wen Liu and co-workers from UT Austin have reported in ACIE on the chemoenzymatic synthesis of spinosyn A.

spinosyn A

 

ACIE paper

Posted in Chemical Biology, Chemoenzymatic | Leave a Comment »