Posted by naturalproductman on April 8, 2016
David Hughes at Cidara Therapeutics reported in ORPD on a patent literature search pertaining the use of biocatalysts to effect chemical transformations. He covers some P450 mediated cyclopropanation, reductive amination, Diels-Alder (artificial enzyme), nitrilase (conversion of nitrile to carboxylic acid) reactions all catalyzed by enzymes.
Posted in Biocatalysis, Chemical Biology, Chemoenzymatic, Enzymatic | Leave a Comment »
Posted by naturalproductman on October 11, 2014
Hung-Wen Liu and co-workers from UT Austin have reported in ACIE on the chemoenzymatic synthesis of spinosyn A.
Posted in Chemical Biology, Chemoenzymatic | Leave a Comment »