Nuno Maulide and co-workers from the University of Vienna have reported in JOC on an intramolecular cyclopropanation from a sulfur slide precursor and what follows is a nice mechanistic investigation.
Posted by naturalproductman on May 2, 2015
Jeffrey Aube (University of Kansas) and Dean Tantillo (UC Davis) have teamed up to study the mechanism of a domino acylation-Diels Alder reaction.
Posted by naturalproductman on May 6, 2014
Another Houk collaboration – this time with Grubbs’ lab. They studied the mechanism of the carboxylate assisted C-H activation of the metathesis catalyst. The SDD basis set was used to approximate the orbitals of ruthenium in this report.
Posted by naturalproductman on May 9, 2013
Laszlo Kurti and co-workers from UT Southwestern have reported in JACS on a [3,3]-sigmatropic rearrangement approach to access BINAM derivatives using a phosphoric acid catalyst.
Posted by naturalproductman on April 19, 2013
Benjamin List and co-workers have reported in JACS on their studies of cinchona alkaloid catalyzed asymmetric epoxidation of activated olefins.
Posted by naturalproductman on January 17, 2013
R. Thomas Williamson and co-workers at Merck have reported in Organic Letters on the use of DFT to calculate and assign stereochemistry from the C-C coupling constants in NMR.
Posted by naturalproductman on November 16, 2012
Dirk Menche and co-workers from the Universitat Bonn have reported in Organic Letters on a synthesis and stereochemical assignment from a bioinformatics study.