Naturalproductman’s Blog

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Archive for the ‘Dimer’ Category

Alkaloid dimer syntheses

Posted by naturalproductman on January 19, 2016

Mohammad Movassaghi and co-workers reported in JACS on the syntheses of (+)-asperazine (1), (+)-iso-pestalazine A (2), and (+)-pesta-lazine A (3).

 

JACS paper

Posted in Alkaloids, Dimer, Total Synthesis | Leave a Comment »

Asperchalasine A

Posted by naturalproductman on September 3, 2015

Here’s a natural product isolation paper that was published in ACIE. Yonghui Zhang and co-workers report on the isolation of asperchalasine A, which induced G-1 phase cell cycle arrest by reducing the expression of cyclin A, CDK2, and CDK6 in cancer cells but not in normal cells at 20 micromolar (pretty high concentration so not so potent in my opinion).

asperchalasine A

ACIE paper

Posted in Cancer, Chemical Biology, Dimer, Terpenoids | Leave a Comment »

Leucoridine synthesis

Posted by naturalproductman on August 28, 2015

Rodrigo Andrade and co-workers from Temple University have reported in ACIE on the synthesis of

Diels-Alder

ACIE paper

Posted in Alkaloids, Diels-Alder, Dimer, Methodology, Named Reactions, Total Synthesis | Leave a Comment »

Sarglabolides A-K

Posted by naturalproductman on July 13, 2015

Long-Yi Kong and co-workers from China Pharmaceutical University have reported in Tetrahedron on the isolation of sarglabolides that inhibited NO production (2.33 micromol/L).

sarglabolides

Tetrahedron paper

Posted in Dimer, Sesquiterpenes | Leave a Comment »

Towards naphthocyclinones

Posted by naturalproductman on July 1, 2015

Keisuke Suzuki and co-workers at the Tokyo Institute of Technology have reported in ACIE on their strategy towards Naphthocyclinones.

polyketide

ACIE paper

Posted in Antibiotics, Dimer, Polyketides | Leave a Comment »

Resveratrol dimer synthesis

Posted by naturalproductman on February 22, 2015

Corey Stephenson at the University of Michigan have reported in ACIE on the synthesis of resveratrol dimers.

dimers

ACIE paper

Posted in Dimer, Total Synthesis | Leave a Comment »

Ramonanins A-D synthesis

Posted by naturalproductman on December 15, 2014

Michael Sherburn and co-workers at Australian National University have reported in ACIE on the synthesis of ramonanins A-D.

ramonanins

ACIE paper

Posted in Dimer, Total Synthesis | Leave a Comment »

Mogolides A and B syntheses

Posted by naturalproductman on November 28, 2014

Yefeng Tang and co-workers from Tsinghua University have reported in ACIE on the synthesis mogolides A and B.

biomimetic

ACIE paper

Posted in Diels-Alder, Dimer, Named Reactions, Polyketides, Total Synthesis | Leave a Comment »

Dimerization, electrochemically

Posted by naturalproductman on April 18, 2014

Phil Baran and co-workers reported in JACS on a synthesis of dixiamycin via electrochemical dimerization. I usually think of Kevin Moeller from Washington University in St. Louis when I see electrochemical reactions.

JACS paper

Posted in Dimer, Electrochemical, Indoles, Methodology, Total Synthesis | Leave a Comment »

Power of enzymes

Posted by naturalproductman on March 30, 2014

Kenji Watanabe and co-workers at Shizuoka University have reported in Chembiochem on the formation of dimeric diketopiperazine alkaloids from a cytochrome P450.

 

Chembiochem paper

Posted in Alkaloids, Cascade Reactions, Dimer, Methodology, Radical Chemistry | Leave a Comment »