Phenalenone Derivatives

Gabriele Konig and co-workers at the University of Bonn in Germany have published in Organic and Biomolecular Chemistry on the isolation of phenalenone derivatives from marine-derived fungus Coniothyrium cereale that were found to inhibit human leukocyte elastase (HLE) at 7.2 to 10.9 micromolar IC50 values. The activity of HLE, a chymotrypsin, has implications in pulmonary emphysema, rheumatoid arthritis, and cystic fibrosis.

Physalin F and Arthritis

Milena Soares and co-workers at Centro de Pesquisas Goncalo Moniz, Fundao Oswaldo Cruz in Brazil have published in the Journal of Natural Products on the effects of physalin F on arthritis.

 

JNP paper