Gabriele Konig and co-workers at the University of Bonn in Germany have published in Organic and Biomolecular Chemistry on the isolation of phenalenone derivatives from marine-derived fungus Coniothyrium cereale that were found to inhibit human leukocyte elastase (HLE) at 7.2 to 10.9 micromolar IC50 values. The activity of HLE, a chymotrypsin, has implications in pulmonary emphysema, rheumatoid arthritis, and cystic fibrosis.
Archive for the ‘Arthritis’ Category
Phenalenone Derivatives
Posted by naturalproductman on January 24, 2011
Posted in Aromatic, Arthritis, Cystic Fibrosis, Diseases, Emphysema, human leukocyte elastase, Phenalenones, Polyketides, Protein Targets | Leave a Comment »
Physalin F and Arthritis
Posted by naturalproductman on August 3, 2010
Milena Soares and co-workers at Centro de Pesquisas Goncalo Moniz, Fundao Oswaldo Cruz in Brazil have published in the Journal of Natural Products on the effects of physalin F on arthritis.
Posted in Arthritis, Steroids | Leave a Comment »