Posted by naturalproductman on January 24, 2011
Gabriele Konig and co-workers at the University of Bonn in Germany have published in Organic and Biomolecular Chemistry on the isolation of phenalenone derivatives from marine-derived fungus Coniothyrium cereale that were found to inhibit human leukocyte elastase (HLE) at 7.2 to 10.9 micromolar IC50 values. The activity of HLE, a chymotrypsin, has implications in pulmonary emphysema, rheumatoid arthritis, and cystic fibrosis.
Posted in Aromatic, Arthritis, Cystic Fibrosis, Diseases, Emphysema, human leukocyte elastase, Phenalenones, Polyketides, Protein Targets | Leave a Comment »
Posted by naturalproductman on August 3, 2010
Milena Soares and co-workers at Centro de Pesquisas Goncalo Moniz, Fundao Oswaldo Cruz in Brazil have published in the Journal of Natural Products on the effects of physalin F on arthritis.
Posted in Arthritis, Steroids | Leave a Comment »