Chien-Chang Shen and co-workers from Hung Kuang University and National Yang-Ming University in Taiwan have reported in the Journal of Natural Products on the isolation of erinacine S, which had increased the expression of an insulin-degrading enzyme in the cerebral cortex.
Archive for the ‘Diabetes Type 2’ Category
Posted by naturalproductman on February 2, 2016
Posted by naturalproductman on January 19, 2016
Jian-Min Yue and co-workers from the Chinese Academy of Sciences have reported in Organic Letters on the isolation of cipacinoids A-D, which had protein tyrosine phosphatase 1B inhibition (17 micromolar).
Posted by naturalproductman on October 23, 2012
Here’s a study by Zhong-Yin Zhang and co-workers at Indiana University on a PTP-MEG2 inhibitor.
Posted by naturalproductman on June 19, 2011
Jinq-Chyi Lee and co-workers at the Institute of Biotechnology and Pharmaceutical research in Taiwan have reported in Chemistry a European Journal on a polyne natural product that has anti-diabetic activity.
Posted by naturalproductman on March 3, 2011
Tatanans were isolated from the rhizomes of Acorus tatarinowii Schott by De-Quan Yu and co-workers at the Chinese Academy of Medical Sciences and Peking Union Medical College. These compounds were found to have antihyperglycemic activity with EC1.5 values ranging from 0.16−1.85 μM.
Posted by naturalproductman on February 14, 2011
Anjali Ruikar and co-workers have reported the isolation of some compounds dubbed pallensin from the plant Artemisia pallens WALLS ex DC. The methanol extract of the plant was found to have anti-diabetic activities.
Posted by naturalproductman on December 6, 2010
Johannes Imhoff and co-workers at Leibniz-Institute of Marine Sciences have published in the Journal of Natural Products on the isolation of eutypoids B-E from the Penicillium sp. strain KF620 i. Eutypoid B had an IC50 of 0.78 micromolar against glycogen synthase kinase-3β (GSK-3β), which is a target for treating type 2 diabetes and Alzheimer’s disease.
Posted by naturalproductman on November 22, 2010
Pascal Wafo and co-workers from France have published in Organic Letters on the isolation of duboscic acid. It had alpha-glucosidase inhibition activity with with an IC50 value of 100 ± 8.1 μM. So you might wonder why alpha-glucosidase inhibition is important – alpha-glucosidase is an enzyme that hydrolyzes disaccharides into monosaccharides so the inhibition of this enzyme should slow down the absorption of glucose in people, which is especially important in diabetic patients.
Posted by naturalproductman on March 20, 2010
Thomas Paululat and co-workers at the University of Siegen in Germany have recently reported on the isolation of grecocycline B from Streptomyces sp. Acta 1362. The new polycyclic compound had an IC50 of 0.52 micromolar against tyrosine phosphatase B1. Interestingly, protein tyrosine phosphatase PTP1B is a target for the treatment of obesity, type 2 diabetes and cancer.