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Archive for the ‘Macrolides’ Category

Antarlides

Posted by naturalproductman on January 26, 2016

Masaya Imoto and co-workers from Keio University have reported in ACIE on some macrolides that acted as androgen receptor antagonists.

 

ACIE paper

Posted in Cancer, Macrocycles, Macrolides | Leave a Comment »

Mandelalide A synthesis

Posted by naturalproductman on January 18, 2016

Rich Carter and co-workers have reported in JACS on the synthesis of mandelalide.

 

 

JACS paper

Posted in Macrocycles, Macrolides, Total Synthesis | Leave a Comment »

Terreumols A and C syntheses

Posted by naturalproductman on January 18, 2016

Thomas Lindel and co-workers from Technical University Braunschweig have reported in ACIE on the synthesis of terreumols A and C.

 

ACIE paper

Posted in Macrolides, Total Synthesis | Leave a Comment »

Fijiolide A synthesis

Posted by naturalproductman on August 27, 2015

Nicolai Cramer and colleague from EPFL have reported in JACS on the synthesis of fijiolide A.

fijiolide

JACS paper

Posted in Aromatic, Macrolides, Total Synthesis | Leave a Comment »

Molecular prosthetics

Posted by naturalproductman on August 7, 2015

Martin Burke’s group is making use of their small molecules that they’re synthesizing.
prosthetic
JACS paper

Posted in Chemical Biology, Macrolides, Methodology, Polyenes, Polyketides | Leave a Comment »

Nannocystin A

Posted by naturalproductman on July 17, 2015

Dominic Hoepfner and co-workers from Novartis have reported in ACIE on nannocystin A, which had similar binding properties with didemin B on EF-1alpha (elongation factor 1 inhibitor).

nannocystin A

ACIE paper

Mark Brönstrup and co-workers at Helmholtz Zentrum für Infektionsforschung also reported on the isolation of this small molecule. I wonder if there’s a relationship between the two studies.

ACIE paper

the novartis paper states that their study parallels the work in helmholtz. I guess the two studies just coincidentally resulted in the isolation of the same compound.

Posted in Biosynthesis, Cancer, Chemical Biology, Macrocycles, Macrolides, Peptides | Leave a Comment »

Muironolide A synthesis

Posted by naturalproductman on May 4, 2015

Armen Zakarian and co-workers have reported in JACS on the synthesis of muironolide A.

muironolide A

JACS paper

Posted in Macrolides, Structural Reassignment, Total Synthesis | Leave a Comment »

5,6-Dihydrocineromycin B synthesis

Posted by naturalproductman on April 16, 2015

Alois Furstner and co-workers have reported in ACIE on the synthesis of 5,6-dihydrocineromycin B.
lactone
ACIE paper

Posted in cross coupling, Macrolides, Named Reactions, Total Synthesis | Leave a Comment »

Tiacumicin B (Lipiarmycin A3/Fidaxomicin) aglycone synthesis

Posted by naturalproductman on December 15, 2014

Karl Heinz-Altmann and co-workers at ETH Zurich have reported in ACIE on the synthesis of fidaxomicin aglycone.

fidaxomicin

ACIE paper

Posted in Macrolides, Polyenes, Polyketides, Total Synthesis | Leave a Comment »

Cochliomycin synthesis via NHK

Posted by naturalproductman on November 29, 2014

Martin Banwell and co-workers at the Australian National University have reported in JOC on the synthesis of cochliomycins A and B.

cochliomycins

JOC paper

Posted in cross coupling, Macrolides, Metathesis, Methodology, Named Reactions, Polyketides, Total Synthesis | Leave a Comment »

 
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