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Archive for the ‘Methodology’ Category

Ni-catalyzed cyclopropanation

Posted by naturalproductman on July 30, 2015

Peter Chen and co-workers from ETH Zurich have reported in ACIE on a nickel catalyzed cyclopropanation. Looks similar to a Corey-Chaykovsky cyclopropanation because of the formation of an ylide.

nickel

ACIE paper

Posted in Carbene, Cascade Reactions, Methodology, Nickel, Transition Metal | Leave a Comment »

Hydroamidocarbonylation

Posted by naturalproductman on July 30, 2015

Matthias Keller and co-workers have reported in ACIE on a hydroamidocarbonylation of olefins.
hydroamidocarbonylation

ACIE paper

Posted in Cascade Reactions, Methodology, Palladium, Transition Metal | Leave a Comment »

Cannizzaro cascade

Posted by naturalproductman on July 30, 2015

Simon Woodward and co-workers have reported in ACIE on a Cannizzaro cascade reaction using tert-butyl lithium.
cascade
ACIE paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling | Leave a Comment »

4pi-Electrocyclic ring opening cascade

Posted by naturalproductman on July 23, 2015

Kiyosei Takasu and co-workers from Kyoto University have reported in JACS on a ring expansion cross coupling cascade.

JACS paper

Posted in Cascade Reactions, Electrocyclization, Methodology, Palladium, Transition Metal | Leave a Comment »

Penibruguieramine A synthesis

Posted by naturalproductman on July 22, 2015

Sanghee Kim and co-workers from Seoul National University have reported in ACIE on the synthesis of penibruguieramine A.

alkaloid

ACIE paper

Posted in Alkaloids, Asymmetric, Kinetic resolution, Methodology, Total Synthesis | Leave a Comment »

Hosieine A synthesis

Posted by naturalproductman on July 22, 2015

Ran Hong and co-workers at SIOC have reported in ACIE on the synthesis of hosieine A. The pyridone moiety reminds of lyconadin.

alkaloid

ACIE paper

Posted in Alkaloids, Cascade Reactions, Methodology, Total Synthesis | Leave a Comment »

Iron cross coupling with vinyl acetates

Posted by naturalproductman on July 17, 2015

Axel Jacobi von Wangelin and co-workers at the University of Regensburg have reported in ACIE on an iron catalyzed cross coupling between alkenyl acetates and an alkyl magnesium halide unit.

iron

ACIE paper

Posted in cross coupling, Iron, Transition Metal | Leave a Comment »

Machines in organic synthesis

Posted by naturalproductman on July 17, 2015

Steven Ley and co-workers reported in ACIE on a review of the different machines people use to make small molecules. I like the use of actual photographs of the equipment…

photos

ACIE paper

Posted in Methodology, New Setups, New Types | Leave a Comment »

Blue-LED induced cascade

Posted by naturalproductman on July 17, 2015

Zhiyong Jiang and co-workers from Henan University have reported in ACIE on a radical cascade cyclization using blue light emitted diodes.

radical

ACIE paper

Posted in Cascade Reactions, Light Mediated, Methodology, Radical Chemistry | Leave a Comment »

Pyridinium catalyzed glycosylation

Posted by naturalproductman on July 17, 2015

Albrecht Berkessel and co-workers at Cologne University have reported in ACIE on a pyridinium catalyzed glycosylation reaction.
pyridinium
ACIE paper

Posted in Cascade Reactions, Methodology, Organocatalytic | Leave a Comment »

 
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