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Archive for the ‘Methodology’ Category

Photoredox cross-coupling

Posted by naturalproductman on August 31, 2015

Larry Overman and co-workers reported in JACS on a photoredox coupling between tertiary alcohols and electron deficient olefins.

JACS paper

Posted in cross coupling, Light Mediated, Methodology | Leave a Comment »

Aryl bromide and aryl triflate cross coupling with Ni and Pd

Posted by naturalproductman on August 28, 2015

Daniel Weix and co-workers have reported in Nature on a multimetallic cross coupling between an aryl triflate and aryl bromide using palladium and nickel.

Nature paper

Posted in Cooperative Catalysis, cross coupling, Methodology, Nickel, Palladium, Transition Metal | Leave a Comment »

Fe-catalyzed [2+2]

Posted by naturalproductman on August 28, 2015

Paul Chirik and co-workers from Princeton have reported in Science on an iron catalyzed [2+2] cycloaddition.

Science paper

Posted in Cycloaddition, Iron, Transition Metal, [2+2] | Leave a Comment »

Regioselective acylation

Posted by naturalproductman on August 28, 2015

Takeo Kawabata and co-workers from Kyoto University have reported in ACIE on the synthesis of multifidosides through a regioselective acylation.

acylation

ACIE paper

Posted in Glycosides, Methodology, Regioselective, Total Synthesis | Leave a Comment »

Leucoridine synthesis

Posted by naturalproductman on August 28, 2015

Rodrigo Andrade and co-workers from Temple University have reported in ACIE on the synthesis of

Diels-Alder

ACIE paper

Posted in Alkaloids, Diels-Alder, Dimer, Methodology, Named Reactions, Total Synthesis | Leave a Comment »

Amine trapping

Posted by naturalproductman on August 28, 2015

John Wolfe and co-workers have reported in JACS on a palladium catalyzed carboamination.

indane

JACS paper

Posted in Asymmetric, Methodology, Palladium, Transition Metal | Leave a Comment »

Vinyl chlorides from terminal alkynes

Posted by naturalproductman on August 26, 2015

Silvie Derien and co-workers from CNRS have reported in ACIE on a ruthenium catalyzed hydrochlorination of alkynes.

 

ACIE paper

Posted in Methodology, Ruthenium, Transition Metal | Leave a Comment »

Bicyclomycin formal synthesis

Posted by naturalproductman on August 26, 2015

Ullrich Jahn and co-workers from the Academy of the Sciences of the Czech Republic reported in ACIE on a formal synthesis of bicyclomycin.
radical
ACIE paper

Posted in Alkaloids, Cascade Reactions, Methodology, Total Synthesis | Leave a Comment »

Diels-Alder approach to galbulimima alkaloids

Posted by naturalproductman on August 25, 2015

Here’s a paper related to the galbulimima alkaloids, which were made famous by Lewis Mander’s group. Regan Thomson and co-workers report in JACS on the synthesis of galbulimima alkaloids. A nice collaboration with DFT calculations from Dean Tantillo’s group shows the orbital interactions in the transition state structures of the Diels-Alder reactions.
galbulimima

JACS paper

Posted in Alkaloids, DFT, Diels-Alder, Methodology, Total Synthesis | Leave a Comment »

retro [2+2] by ultrasonication

Posted by naturalproductman on August 25, 2015

Jeffrey Moore and colleague at UIUC have reported in JACS on a retro Staudinger cycloaddition reaction. I am reminded of the retro-“click” paper.
2+2

JACS paper

Posted in Cycloaddition, Methodology | Leave a Comment »

 
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