Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Methodology’ Category

Steenkrotin A synthesis

Posted by naturalproductman on April 18, 2015

Huanfeng Ding and co-workers from Zhejiang University have reported in ACIE on the synthesis of steenkrotin A.

steenkrotin A

ACIE paper

Posted in Diterpenoids, Methodology, Radical Chemistry, Total Synthesis | Leave a Comment »

Nitriles to amides

Posted by naturalproductman on April 16, 2015

This may be a good alternative to the Ghaffar-Parkins catalyst. Jyotirmayee Dash and co-workers at Indian Association for the Cultivation of Science have reported in JOC on using potassium tert-butoxide to convert nitriles to amides.

amide

JOC paper

Posted in Methodology | 1 Comment »

Reverse Claisen cascade

Posted by naturalproductman on April 16, 2015

Yongjia Shang and co-workers from Anhui Normal University have reported in JOC on an interesting iron catalyzed cascade reaction.

JOC paper

Posted in Cascade Reactions, Claisen rearrangement, Iron, Methodology, Sigmatropic Rearrangements, Transition Metal | Leave a Comment »

Surprisingly deshielded proton

Posted by naturalproductman on April 16, 2015

Normally when you see a benzylic proton, you might think of the chemical shift between 2-3 ppm, and when you think of a proton alpha to a hetero atom such as that of an amide, you might think of a chemical shift in the range of 3-4 ppm, but this example here shows the chemical shift of the combination of a benzylic proton that is also alpha to an amide to be 6.0 ppm. The JOC paper was published by Fernando Sartillo-Piscil and co-workers at Universidad Autónoma de Puebla, México.

Interesting.

JOC paper

Posted in Methodology | Leave a Comment »

Mn catalyzed C-H azidation

Posted by naturalproductman on April 16, 2015

Jay Groves and co-workers have reported in JACS on a Mn-catalyzed C-H azidation reaction.

Mn

JACS paper

Posted in C-H activation, Manganese, Methodology, Transition Metal | Leave a Comment »

Pd-catalyzed DKR

Posted by naturalproductman on April 16, 2015

Xinjun Luan and co-workers have reported in JACS on a palladium catalyzed dynamic kinetic resolution of biaryls to spirocyclic centers.

spirocycle

JACS paper

Posted in Cascade Reactions, Kinetic resolution, Methodology, Palladium, Transition Metal | Leave a Comment »

A Formal Metathesis

Posted by naturalproductman on April 16, 2015

Zhang Jie-Shi and co-workers from the Chinese Academy of Sciences have reported in JACS on a rhodium catalyzed exchange between an aryl keton and an aryl carboxylic acid to form aliphatic carboxylic acids and biaryl compounds.

cascade

JACS paper

Posted in Cascade Reactions, Metathesis, Methodology, Rhodium, Transition Metal | Leave a Comment »

Hypodoratoxide structural revision through 13C-13C COSY

Posted by naturalproductman on April 16, 2015

Jeroen Disckschat and co-workers at Rheinische Friedrich-Wilhelms-Universität Bonn have reported in ACIE on a 13C-13C COSY method to elucidate the structure of hypodoratoxide.
structure

ACIE paper

Posted in Methodology, New Setups, Structural Reassignment | Leave a Comment »

Triyne benzannulation

Posted by naturalproductman on April 16, 2015

Daesung Lee and co-workers have reported in ACIE on a benzannulation of triynes.

benzannulation

ACIE paper

Posted in alkyne, Cascade Reactions, Methodology | Leave a Comment »

Rhodium and triazoles cascade

Posted by naturalproductman on April 16, 2015

When I saw this paper I thought of the stuff Dale Boger does with the triazole cascade reactions.

triazole

ACIE paper

Posted in Cascade Reactions, Methodology, Transition Metal | Leave a Comment »

 
Follow

Get every new post delivered to your Inbox.

Join 78 other followers