Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Methodology’ Category

Cannabimovone synthesis

Posted by naturalproductman on May 29, 2016

Antonio Echavarran and co-workers from ICIQ have reported in ACIE on the synthesis of cannabimovone.

 

ACIE paper

Posted in alkyne, Cascade Reactions, Gold, Methodology, Structural Reassignment, Total Synthesis | Leave a Comment »

Perforanoid A synthesis

Posted by naturalproductman on May 29, 2016

Xiaojiang Hao and co-workers from the Chinese Academy of Sciences have reported in ACIE on the synthesis of perforanoid A.

 

ACIE paper

Posted in Limonoids, Methodology, Pauson-Khand, Total Synthesis | Leave a Comment »

Towards indoxamycin via C-H functionalization

Posted by naturalproductman on May 29, 2016

Erik Sorensen and Huw Davies and co-workers reported in ACIE on a C-H functionalization approach towards indoxamycin.

 

ACIE paper

Posted in C-H activation, Cascade Reactions, Methodology | Leave a Comment »

Methyl ether + Grignard

Posted by naturalproductman on May 29, 2016

Naoto Chatani and co-workers from Osaka University have reported in JACS on a methyl ether coupling reaction with a Grignard reagent.

 

JACS paper

Posted in cross coupling, Methodology, Nickel, Transition Metal | Leave a Comment »

Towards eribulin

Posted by naturalproductman on May 29, 2016

Yoshito Kishi and colleague have reported in JACS on a coupling reaction between a thioester and an alkyl bromide.

 

JACS paper

Posted in Cascade Reactions, Methodology, Radical Chemistry | Leave a Comment »

Iron-catalyzed cross coupling between Grignard reagents and enol carbamates

Posted by naturalproductman on May 3, 2016

Doug Frantz and co-workers from UTSA have reported in ACIE on an iron-catalyzed cross-coupling reaction between enol carbamates and Grignard reagents.

 

ACIE paper

Posted in cross coupling, Iron, Methodology, Transition Metal | Leave a Comment »

Propargylic benzoate to allene

Posted by naturalproductman on April 19, 2016

Erick Carreira and colleague have reported in Organic Letters on a rhodium catalyzed synthesis of chiral allenes from propargylic benzoates.

 

OL paper

Posted in Allenes, Methodology, Rhodium, Transition Metal | Leave a Comment »

Markovnikov addition – terminal alkynes to ketones

Posted by naturalproductman on April 19, 2016

Chao-Jun Li and co-workers from McGill University reported in Organic Letters on a useful transformation that converts a terminal alkyne to a ketone using trifluoroethanol as the solvent and triflic acid.

 

OL paper

Posted in Alkynes, Cascade Reactions, Methodology | Leave a Comment »

From a dithiane-vinyl chloride to furan

Posted by naturalproductman on April 19, 2016

Shouchu Tang and co-workers from Lanzhou University have reported in Organic Letters on an interesting transformation that undergoes an allene intermediate.

 

OL paper

Posted in Cascade Reactions, Mechanistic, Methodology | Leave a Comment »

Desymmetrization with proline and Pd

Posted by naturalproductman on April 19, 2016

Yi-Xia Jia and co-workers from Zhejiang University have reported in JACS on an intramolecular desymmetrization by a Heck reaction.

 

JACS paper

Posted in Desymmetrization, Heck, Methodology, Mizoroki-Heck, Organocatalytic, Palladium, Transition Metal | Leave a Comment »

 
Follow

Get every new post delivered to your Inbox.

Join 83 other followers