Naturalproductman’s Blog

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Archive for the ‘Methodology’ Category

Cope rearrangement

Posted by naturalproductman on August 23, 2016

James Gleason and colleague at McGill University have reported in ACIE on an organocatalytic Cope rearrangement.

 

ACIE paper

Posted in Cascade Reactions, Methodology, Organocatalytic, Sigmatropic Rearrangements | Leave a Comment »

Carbonylative spirolactonization

Posted by naturalproductman on August 22, 2016

Mingji Dai and co-workers reported in JACS on a Pd-catalyzed spirolactonization.

 

JACS paper

Posted in Cascade Reactions, Methodology, Palladium | Leave a Comment »

Spinosyn A synthesis

Posted by naturalproductman on August 22, 2016

Mingji Dai and co-workers at Purdue reported in JACS on the synthesis of spinosyn A through a carbonylative macrolactonization.

 

JACS paper

Posted in Cascade Reactions, Methodology, Total Synthesis | Leave a Comment »

Transamination reaction

Posted by naturalproductman on August 22, 2016

Here’s a transamination reaction reported in JACS. Normally pyridoxal-phosphate containing enzymes do this in nature but this is the biomimetic approach.

 

JACS paper

Posted in Cascade Reactions, Methodology, Organocatalytic | Leave a Comment »

Triiodide-mediated C-H amination

Posted by naturalproductman on July 31, 2016

David Nagib and co-workers from the Ohio State University have reported in ACIE on a triiodide mediated C-H amination reaction.

 

ACIE paper

Posted in C-H activation, Hypervalent Iodine, Methodology | Leave a Comment »

Amidation-C-H activation cascade

Posted by naturalproductman on July 31, 2016

Santhosh Mhaske and colleague at CSIR have reported in Organic Letters on a palladium catalyzed amidation-C-H activation cascade.
OL paper

Posted in Cascade Reactions, Methodology, Palladium, Transition Metal | Leave a Comment »

Diyne to cyclohexenone

Posted by naturalproductman on July 31, 2016

Radomir Salicic and co-workers from the University of Belgrade have reported in Organic Letters on a gold catalyzed cascade cyclization of a diyne.

 

OL paper

Posted in Cascade Reactions, Gold, Methodology, Transition Metal | Leave a Comment »

Enol triflates to alkynes

Posted by naturalproductman on July 31, 2016

Doug Frantz and colleague have reported in Organic Letters on a Pd-catalyzed conversion of a vinyl triflate to a disubstituted alkyne.

 

OL paper

Posted in Cascade Reactions, Methodology, Palladium, Transition Metal | Leave a Comment »

From vinyl azides to alpha-fluoroketones

Posted by naturalproductman on July 31, 2016

Feng Liu and colleague at Soochow University reported in Organic Letters on using Selectfluor to convert vinyl azides to alpha-fluoroketones.

 

OL paper

Posted in Cascade Reactions, Mechanistic, Methodology | Leave a Comment »

Chiral Anion Phase Transfer (CAPT)

Posted by naturalproductman on July 30, 2016

Dean Toste and co-workers have reported in JACS on the enantioselective synthesis of flavonoids using CAPT.

 

JACS paper

Posted in Asymmetric, Polyketides, Total Synthesis | Leave a Comment »

 
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