Naturalproductman’s Blog

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Archive for the ‘Methodology’ Category

Debromohamigeran E synthesis

Posted by naturalproductman on July 3, 2015

James Morken and colleague at Boston College have reported in JACS on the synthesis of debromohamigeran E.
boron
JACS paper

Posted in cross coupling, Methodology, Total Synthesis | Leave a Comment »

From carbenoids to allenoates

Posted by naturalproductman on July 1, 2015

Xiaoming Feng and co-workers from Sichuan University have reported in the transformation of terminal alkynes to allenoates using diazo acetates.

diazo

ACIE paper

Posted in Carbene, Methodology, Organocatalytic | Leave a Comment »

Binaphthylamine catalyzed Michael addition

Posted by naturalproductman on July 1, 2015

When I saw that binaphthylamine on the abstract, I immediately thought of Keiji Maruoka and it was his work.

arylamine

ACIE paper

Posted in Methodology, Michael, Named Reactions, Organocatalytic | Leave a Comment »

From Terminal Diols to Secondary Alcohols

Posted by naturalproductman on July 1, 2015

Bill Morandi and colleague at Max-Planck-Institut für Kohlenforschung have reported in ACIE on a deoxygenation strategy of terminal 1,2-diols to secondary alcohols.

secondary alcohol
ACIE paper

Posted in C-X Bond Breaking, Methodology | Leave a Comment »

Alkoxycarbonylation of allenes – regioselective switching by ligand

Posted by naturalproductman on June 30, 2015

Matthias Beller and co-workers have reported in JACS on a ligand controlled regioselectivitiy switching of an alkoxycarbonylation of an allene substrate.

JACS paper

Posted in Methodology, Palladium, Regioselective, Transition Metal | Leave a Comment »

Trichodermamides A, B, and C syntheses

Posted by naturalproductman on June 30, 2015

Oleg Larionov and co-workers at UT San Antonio have reported in JACS on the syntheses of trichodermamides A, B, and C.

polyketide

JACS paper

Posted in Cascade Reactions, Methodology, Total Synthesis | Leave a Comment »

α-Ketol rearrangement

Posted by naturalproductman on June 9, 2015

Ulrich Koert and co-workers from Philipps-University Marburg have reported in Organic Letters on an alpha-ketol rearrangment.They heat the reaction in a sealed tube to 70 degrees and the solvent is in DCM – with 2.5 mol equivalents of BF3 etherate, sounds a bit harsh – but nonetheless an interesting sigmatropic rearrangement.

 
ketol
OL paper

Posted in Cascade Reactions, Mechanistic, Methodology | Leave a Comment »

Cyclic 1,3-carbonates from carbon dioxide fixation

Posted by naturalproductman on June 7, 2015

Jeffrey Johnston and co-workers have reported in JACS on the synthesis of 1,3-cyclic carbonates from butenol, carbon dioxide and NIS.
carbonate
JACS paper

Posted in Asymmetric, Methodology, Organocatalytic | Leave a Comment »

Ru-catalyzed metathesis of fluoro-olefins and enol ethers

Posted by naturalproductman on June 6, 2015

Yusuke Takahira and colleague at Asahi Glass Co. have reported in JACS on a cross metathesis between fluoro-olefins and enol ethers.

metathesis

JACS paper

Posted in Metathesis, Ruthenium, Transition Metal | Leave a Comment »

Nodulisporic acid D synthesis

Posted by naturalproductman on June 6, 2015

Amos Smith and co-workers have reported in JACS on the synthesis of nodulisporic acid D.

alkaloid

JACS paper

Posted in Alkaloids, Total Synthesis, Transition Metal | Leave a Comment »

 
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