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Archive for the ‘Asymmetric’ Category

Amine trapping

Posted by naturalproductman on August 28, 2015

John Wolfe and co-workers have reported in JACS on a palladium catalyzed carboamination.

indane

JACS paper

Posted in Asymmetric, Methodology, Palladium, Transition Metal | Leave a Comment »

Asymmetric copper catalyzed Michael Addition

Posted by naturalproductman on August 19, 2015

Jean-Marc Campagne and co-workers at CNRS have reported in ACIE on a copper catalyzed asymmetric Michael addition.
copper

ACIE paper

Posted in Asymmetric, Copper, Methodology, Transition Metal | Leave a Comment »

Jiadifenolide synthesis

Posted by naturalproductman on August 4, 2015

Ryan Shenvi and co-workers have reported in Nature Chemistry on the synthesis of jiadifenolide.

Nature Chemistry paper

Posted in Asymmetric, Total Synthesis | Leave a Comment »

Penibruguieramine A synthesis

Posted by naturalproductman on July 22, 2015

Sanghee Kim and co-workers from Seoul National University have reported in ACIE on the synthesis of penibruguieramine A.

alkaloid

ACIE paper

Posted in Alkaloids, Asymmetric, Kinetic resolution, Methodology, Total Synthesis | Leave a Comment »

Nazarov-semipinacol cascade

Posted by naturalproductman on July 11, 2015

Take a cyclobutanol bearing dienone and see what kind of Nazarov reaction occurs…Yong-Qiang Tu and co-workers at Lanzhou University reported in JACS on this interesting asymmetric transformation.

Nazarov

JACS paper

Posted in Asymmetric, Cascade Reactions, Methodology, Named Reactions, Nazarov cyclization, Organocatalytic | Leave a Comment »

Stereospecific reaction with D2O but not with H2O

Posted by naturalproductman on July 10, 2015

Jik Choon and co-workers at the University of Toronto have reported in ACIE on an interesting sttereoinversion that occurs in D2O but not in H2O.

asymmetric

ACIE paper

Posted in Asymmetric, Methodology, Organocatalytic | Leave a Comment »

Cyclic 1,3-carbonates from carbon dioxide fixation

Posted by naturalproductman on June 7, 2015

Jeffrey Johnston and co-workers have reported in JACS on the synthesis of 1,3-cyclic carbonates from butenol, carbon dioxide and NIS.
carbonate
JACS paper

Posted in Asymmetric, Methodology, Organocatalytic | Leave a Comment »

Disorazole synthesis through metathesis

Posted by naturalproductman on May 2, 2015

Alison Hulme and co-workers from the University of Edinburgh have reported in ACIE on a metathesis approach to disorazole. Reminds me of the Hoveyda approach.

metathesis

ACIE paper

Posted in Asymmetric, C2-Symmetric, Metathesis, Methodology, Molybdenum, Transition Metal | Leave a Comment »

Galanthamine and lycoramine syntheses

Posted by naturalproductman on April 12, 2015

Yanxing Jia and co-workers at Peking University have reported in ACIE on the synthesis galanthamine and lycoramine.
galanthamine

ACIE paper

Posted in Alkaloids, Asymmetric, Methodology, Total Synthesis, Transition Metal | Leave a Comment »

Intramolecular nucleophilic displacement of alcohols

Posted by naturalproductman on April 12, 2015

Joseph Samec and co-workers from the University of Uppsala have reported in JACS on a phosphoric acid catalyzed intramolecular displacement of alcohols.

alcohol

JACS paper

Posted in Asymmetric, Methodology | Leave a Comment »

 
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