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Archive for the ‘Asymmetric’ Category

Cyclic 1,3-carbonates from carbon dioxide fixation

Posted by naturalproductman on June 7, 2015

Jeffrey Johnston and co-workers have reported in JACS on the synthesis of 1,3-cyclic carbonates from butenol, carbon dioxide and NIS.
carbonate
JACS paper

Posted in Asymmetric, Methodology, Organocatalytic | Leave a Comment »

Disorazole synthesis through metathesis

Posted by naturalproductman on May 2, 2015

Alison Hulme and co-workers from the University of Edinburgh have reported in ACIE on a metathesis approach to disorazole. Reminds me of the Hoveyda approach.

metathesis

ACIE paper

Posted in Asymmetric, C2-Symmetric, Metathesis, Methodology, Molybdenum, Transition Metal | Leave a Comment »

Galanthamine and lycoramine syntheses

Posted by naturalproductman on April 12, 2015

Yanxing Jia and co-workers at Peking University have reported in ACIE on the synthesis galanthamine and lycoramine.
galanthamine

ACIE paper

Posted in Alkaloids, Asymmetric, Methodology, Total Synthesis, Transition Metal | Leave a Comment »

Intramolecular nucleophilic displacement of alcohols

Posted by naturalproductman on April 12, 2015

Joseph Samec and co-workers from the University of Uppsala have reported in JACS on a phosphoric acid catalyzed intramolecular displacement of alcohols.

alcohol

JACS paper

Posted in Asymmetric, Methodology | Leave a Comment »

Rocaglamide synthesis

Posted by naturalproductman on March 31, 2015

Marcus Tius and colleague have reported in ACIE on the asymmetric synthesis of rocaglamide.
rocaglamide

ACIE paper

Posted in Asymmetric, Named Reactions, Nazarov cyclization, Total Synthesis | Leave a Comment »

[2+2] via oxazaborolidine

Posted by naturalproductman on March 22, 2015

M. Kevin Brown and co-workers at Indiana University have reported in JACS on an asymmetric [2+2] using an oxazaborolidine catalyst.

2+2

JACS paper

Posted in Asymmetric, Cycloaddition, Methodology, [2+2] | Leave a Comment »

Phosphoric acid catalyzed alpha-amination

Posted by naturalproductman on March 5, 2015

Dean Toste and colleague have reported in JACS on a phosphoric acid catalyzed alpha-amination of ketones – I am reminded of Hisashi Yamamoto’s silver BINAP methodology back in 2003.

phosphoric acid

JACS paper

Posted in Asymmetric, Methodology, Organocatalytic | Leave a Comment »

Rh-catalyzed arylation

Posted by naturalproductman on March 5, 2015

Tamio Hayashi and colleague at the National University of Singapore have reported in JACS on a rhodium catalyzed asymmetric arylation of an alkenyl sulfone.

rhodium

JACS paper

Posted in Asymmetric, Methodology, Rhodium, Total Synthesis, Transition Metal | Leave a Comment »

Asymmetric hydrogenation with molecular tweezers

Posted by naturalproductman on March 5, 2015

Tim Repo and co-workers at the University of Helsinki have reported in JACS on the use of chiral molecular tweezers for asymmetric hydrogenation.

molecular tweezers

JACS paper

Posted in Asymmetric, Methodology | Leave a Comment »

Posted by naturalproductman on January 18, 2015

Masahiro Terada and co-workers from Tohoku University have reported in JACS on a kinetic resolution approach to accessing chiral amino-alcohols using a chiral phosphoric acid to form an acetal.

phosphoric

JACS paper

Posted in Asymmetric, Kinetic resolution, Methodology | Leave a Comment »

 
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