Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Chemoselective’ Category

Mask the More Reactive Carbonyl

Posted by naturalproductman on November 3, 2010

David Colby and co-workers from Purdue have just added a useful way to selectively reduce less reactive carbonyls (ie: lactone) over more reactive ones (ie:  ketone) by introducing N,O-dimethylhydroxylamine in the presence of an aluminum reducing agent (DIBAL).

selective reduction


OL paper

Posted in Chemoselective, Methodology | Leave a Comment »