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Archive for the ‘cross coupling’ Category

Metal Catalyzed Cross Coupling Reactions

Debromohamigeran E synthesis

Posted by naturalproductman on July 3, 2015

James Morken and colleague at Boston College have reported in JACS on the synthesis of debromohamigeran E.
boron
JACS paper

Posted in cross coupling, Methodology, Total Synthesis | Leave a Comment »

Towards halichondrins

Posted by naturalproductman on May 12, 2015

I would call the vinyl halide coupling reaction with an aldehyde using chromium/nickel combination a Nozaki Hiyama Kishi coupling, but maybe because the author is one of the people in the named reaction, it wasn’t mentioned in the paper as the “NHK reaction”, but rather, a Ni/Cr-mediated reaction.

halichondrin

JACS paper

JACS paper 2

Posted in Chromium, cross coupling, Methodology, Named Reactions, Nickel, Polyketides, Total Synthesis | Leave a Comment »

5,6-Dihydrocineromycin B synthesis

Posted by naturalproductman on April 16, 2015

Alois Furstner and co-workers have reported in ACIE on the synthesis of 5,6-dihydrocineromycin B.
lactone
ACIE paper

Posted in cross coupling, Macrolides, Named Reactions, Total Synthesis | Leave a Comment »

Reductive Heck reaction

Posted by naturalproductman on April 12, 2015

Yi-Xia Jia and co-workers have reported in JACS on an intramolecular Heck reaction.

Heck

JACS paper

Posted in Cascade Reactions, Heck, Methodology, Named Reactions | Leave a Comment »

Arylsilane for C-H activation

Posted by naturalproductman on April 12, 2015

Jin-Quan Yu and co-workers have reported in JACS on a cross coupling reaction between an aryl silane and a C-H bond.

C-H

JACS paper

Posted in C-H activation, cross coupling, Methodology, Palladium, Transition Metal | Leave a Comment »

Cochliomycin synthesis via NHK

Posted by naturalproductman on November 29, 2014

Martin Banwell and co-workers at the Australian National University have reported in JOC on the synthesis of cochliomycins A and B.

cochliomycins

JOC paper

Posted in cross coupling, Macrolides, Metathesis, Methodology, Named Reactions, Polyketides, Total Synthesis | Leave a Comment »

Synthesis of 6-Deoxypladienolide D, which binds to SF3B1

Posted by naturalproductman on October 28, 2014

Gregg Keaney and co-workers at H3 Biomedicine have reported in Org Lett on the synthesis of 6-deoxypladienolide D.
6-deoxypladienolide D

OL paper

Posted in Named Reactions, Polyketides, Suzuki-Miyaura, Total Synthesis | 1 Comment »

Aryl halide couplings with Sp3-carbons

Posted by naturalproductman on July 27, 2014

Gary Molander and colleagues reported in Science on a photoredox nickel dual catalysis for a cross coupling reaction between an sp3-hybridized organoboron and an aryl halide.

Science paper (Molander)

In the same issue, David Macmillan and co-workers have reported on a photoredox reaction involving a nickel catalyzed coupling between an sp3-alpha-carboxyl and an aryl halide.

Science paper (Macmillan)

 

Posted in Cascade Reactions, cross coupling, Light Mediated, Methodology, Nickel, Transition Metal | Leave a Comment »

Silyl Heck reaction

Posted by naturalproductman on August 30, 2013

Donald Watson and colleague have reported in JACS on silyl Heck variant.

vinyl silyl ethers

JACS paper

Posted in cross coupling, Heck, Methodology, Palladium, Transition Metal | Leave a Comment »

Towards PF-1018

Posted by naturalproductman on April 2, 2013

Dirk Trauner and co-workers at have reported in Organic Letters on a Stille-Diels Alder cascade approach towards PF-1018.

PF-1018

OL paper

Posted in Cascade Reactions, cross coupling, Diels-Alder, Methodology, Named Reactions, Stille | Leave a Comment »

 
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