Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘cross coupling’ Category

Metal Catalyzed Cross Coupling Reactions

Rest in Peace Richard Heck

Posted by naturalproductman on December 9, 2015

ACIE paper

Posted in cross coupling, Heck, Random | Leave a Comment »

Pd-cross coupling with vinylogous enolates

Posted by naturalproductman on October 28, 2015

Troels Skrydstrup and co-workers at Aarhus University have reported in JACS on a palladium catalyzed coupling between Csp2-iodides and vinylogous enolates.
enolate

JACS paper

Posted in cross coupling, Methodology, Palladium, Transition Metal | Leave a Comment »

Leustroducsin B synthesis

Posted by naturalproductman on September 2, 2015

Barry Trost and co-workers have reported in JACS on the synthesis of leustroducsin B (39 steps).

leustroducsin B

JACS paper

Posted in cross coupling, Methodology, Total Synthesis | Leave a Comment »

Photoredox cross-coupling

Posted by naturalproductman on August 31, 2015

Larry Overman and co-workers reported in JACS on a photoredox coupling between tertiary alcohols and electron deficient olefins.

JACS paper

Posted in cross coupling, Light Mediated, Methodology | Leave a Comment »

Aryl bromide and aryl triflate cross coupling with Ni and Pd

Posted by naturalproductman on August 28, 2015

Daniel Weix and co-workers have reported in Nature on a multimetallic cross coupling between an aryl triflate and aryl bromide using palladium and nickel.

Nature paper

Posted in Cooperative Catalysis, cross coupling, Methodology, Nickel, Palladium, Transition Metal | Leave a Comment »

Iron cross coupling with vinyl acetates

Posted by naturalproductman on July 17, 2015

Axel Jacobi von Wangelin and co-workers at the University of Regensburg have reported in ACIE on an iron catalyzed cross coupling between alkenyl acetates and an alkyl magnesium halide unit.

iron

ACIE paper

Posted in cross coupling, Iron, Transition Metal | Leave a Comment »

Debromohamigeran E synthesis

Posted by naturalproductman on July 3, 2015

James Morken and colleague at Boston College have reported in JACS on the synthesis of debromohamigeran E.
boron
JACS paper

Posted in cross coupling, Methodology, Total Synthesis | Leave a Comment »

Towards halichondrins

Posted by naturalproductman on May 12, 2015

I would call the vinyl halide coupling reaction with an aldehyde using chromium/nickel combination a Nozaki Hiyama Kishi coupling, but maybe because the author is one of the people in the named reaction, it wasn’t mentioned in the paper as the “NHK reaction”, but rather, a Ni/Cr-mediated reaction.

halichondrin

JACS paper

JACS paper 2

Posted in Chromium, cross coupling, Methodology, Named Reactions, Nickel, Polyketides, Total Synthesis | Leave a Comment »

5,6-Dihydrocineromycin B synthesis

Posted by naturalproductman on April 16, 2015

Alois Furstner and co-workers have reported in ACIE on the synthesis of 5,6-dihydrocineromycin B.
lactone
ACIE paper

Posted in cross coupling, Macrolides, Named Reactions, Total Synthesis | Leave a Comment »

Reductive Heck reaction

Posted by naturalproductman on April 12, 2015

Yi-Xia Jia and co-workers have reported in JACS on an intramolecular Heck reaction.

Heck

JACS paper

Posted in Cascade Reactions, Heck, Methodology, Named Reactions | Leave a Comment »

 
Follow

Get every new post delivered to your Inbox.

Join 83 other followers