Archive for the ‘Stille’ Category
Posted by naturalproductman on April 2, 2013
Dirk Trauner and co-workers at have reported in Organic Letters on a Stille-Diels Alder cascade approach towards PF-1018.

OL paper
Posted in Cascade Reactions, cross coupling, Diels-Alder, Methodology, Named Reactions, Stille | Leave a Comment »
Posted by naturalproductman on December 2, 2011
Kathlyn Parker and colleague have reported in JACS on a synthesis of arabilin, an androgen receptor antagonist that can potentially treat prostate cancer (IC50 of 11 micromolar towards AR). A 1,7-hydride shift occured in their key Stille coupling to afford the correct isomer.

JACS paper
Posted in Cancer, Cascade Reactions, cross coupling, Hydride Shift, Methodology, prostate, Protein Targets, Proteins, Receptors, Stille, Transition Metal | Leave a Comment »
Posted by naturalproductman on January 24, 2011
Albert Padwa and co-workers at Emory have reported on a [4+2] reaction to access the pyridine ring in haplophytine.

Synlett paper
Posted in Cascade Reactions, cross coupling, Cycloaddition, Methodology, Palladium, Pericyclic reactions, Stille, Transition Metal | Leave a Comment »
Posted by naturalproductman on September 17, 2010
Michael Burkhart and co-workers at UCSD have published in Organic Letters on their progress towards the synthesis of spirohexenolide.

OL paper
Posted in cross coupling, Macrocycles, Methodology, Palladium, Stille, Transition Metal | Leave a Comment »
Posted by naturalproductman on September 13, 2010
Markus Kalesse and co-workers at Leibniz Universitat Hannover in Germany have published in JACS on the total synthesis of Chivosazole.

JACS paper
Posted in Ando olefination, cross coupling, Macrocycles, Macrolides, Methodology, Named Reactions, Stille, Wittig | Leave a Comment »
Posted by naturalproductman on July 20, 2010
Steven Ley and co-workers at the University of Cambridge have published in ACIEE on the total synthesis of chloptosin. A Stille cross coupling was employed to furnish the dimer using palladium and AsPh.

ACIEE paper
Posted in Cascade Reactions, cross coupling, Methodology, Organocatalytic, Palladium, Stille, Total Synthesis, Transition Metal | Leave a Comment »
Posted by naturalproductman on June 28, 2010
Richard Taylor and co-workers at the University of York have published in ACIEE on the synthesis of dictyosphaeric acid. They reassigned the stereochemistry of the diol from the originally proposed structure.

ACIEE paper
Posted in Cascade Reactions, Conjugate Additions, cross coupling, Ito-Saegusa oxidation, Methodology, Michael, Named Reactions, Palladium, Polyketides, Stille | Leave a Comment »
Posted by naturalproductman on April 8, 2010
Cheon-Gyu Cho’s group at Hanyang University have recently reported in Organic Letters on the synthesis of galanthamine.

OL paper
Posted in Alkaloids, Cascade Reactions, cross coupling, Cycloaddition, Diels-Alder, Methodology, Named Reactions, Pericyclic reactions, Stille | Leave a Comment »
Posted by naturalproductman on February 1, 2010
A Stille-Heck Cascade reaction has been reported in Organic and Biomolecular Chemistry by Bernard Flynn and co-worker at the Monash Institute of Pharmaceutical Sciences in Australia for the application in the synthesis of frondosin.

OBC paper
Posted in Conjugate Additions, cross coupling, Heck, Methodology, Palladium, Stille, Transition Metal | Leave a Comment »