Towards PF-1018

Dirk Trauner and co-workers at have reported in Organic Letters on a Stille-Diels Alder cascade approach towards PF-1018.

OL paper

Arabilin synthesis

Kathlyn Parker and colleague have reported in JACS on a synthesis of arabilin, an androgen receptor antagonist that can potentially treat prostate cancer (IC50 of 11 micromolar towards AR).  A 1,7-hydride shift occured in their key Stille coupling to afford the correct isomer.

JACS paper

Haplophytine Progress

Albert Padwa and co-workers at Emory have reported on a [4+2] reaction to access the pyridine ring in haplophytine.

Synlett paper

Almost there!

Michael Burkhart and co-workers at UCSD have published in Organic Letters on their progress towards the synthesis of spirohexenolide.

OL paper

Chivosazole Synthesis

Markus Kalesse and co-workers at Leibniz Universitat Hannover in Germany have published in JACS on the total synthesis of Chivosazole.

JACS paper

Chloptosin Synthesis

Steven Ley and co-workers at the University of Cambridge have published in ACIEE on the total synthesis of chloptosin.   A Stille cross coupling was employed to furnish the dimer using palladium and AsPh.

ACIEE paper

Dictyosphaeric Acid Synthesis

Richard Taylor and co-workers at the University of York have published in ACIEE on the synthesis of dictyosphaeric acid.  They reassigned the stereochemistry of the diol from the originally proposed structure.

ACIEE paper

Galanthamine Synthesis

Cheon-Gyu Cho’s group at Hanyang University have recently reported in Organic Letters on the synthesis of galanthamine.

OL paper

Stille-Heck

A Stille-Heck Cascade reaction has been reported in Organic and Biomolecular Chemistry by Bernard Flynn and co-worker at the Monash Institute of Pharmaceutical Sciences in Australia for the application in the synthesis of frondosin.

OBC paper