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Archive for the ‘Kinetic resolution’ Category

Penibruguieramine A synthesis

Posted by naturalproductman on July 22, 2015

Sanghee Kim and co-workers from Seoul National University have reported in ACIE on the synthesis of penibruguieramine A.

alkaloid

ACIE paper

Posted in Alkaloids, Asymmetric, Kinetic resolution, Methodology, Total Synthesis | Leave a Comment »

Guanacastepene syntheses

Posted by naturalproductman on July 11, 2015

Chin-Kang Sha and colleague from National Tsing-Hua University have reported in Organic Letters on the syntheses of guanacastapenes N and O.

guanacastepene

OL paper

Posted in Copper, Diels-Alder, Kinetic resolution, Methodology, Named Reactions, Radical Chemistry, Sesquiterpenes, Total Synthesis, Transition Metal | Leave a Comment »

Pd-catalyzed DKR

Posted by naturalproductman on April 16, 2015

Xinjun Luan and co-workers have reported in JACS on a palladium catalyzed dynamic kinetic resolution of biaryls to spirocyclic centers.

spirocycle

JACS paper

Posted in Cascade Reactions, Kinetic resolution, Methodology, Palladium, Transition Metal | Leave a Comment »

Another thing to add to the dynamic kinetic resolution book

Posted by naturalproductman on April 12, 2015

Yu Zhao and co-workers from the National University of Singapore have reported in JACS on an iridium catalyzed dynamic kinetic resolution of a diastereomeric mixture of alcohols to chiral amines using a phosphoric acid ligand.

amine

JACS paper

Posted in Iridium, Kinetic resolution, Transition Metal | Leave a Comment »

Posted by naturalproductman on January 18, 2015

Masahiro Terada and co-workers from Tohoku University have reported in JACS on a kinetic resolution approach to accessing chiral amino-alcohols using a chiral phosphoric acid to form an acetal.

phosphoric

JACS paper

Posted in Asymmetric, Kinetic resolution, Methodology | Leave a Comment »

Posted by naturalproductman on March 7, 2014

Tsutomu Katsuki and co-workers at Kyushu University have reported on a ruthenium catalyzed kinetic resolution of racemic secondary alcohols via oxidation.

ruthenium

ACIE paper

Posted in Asymmetric, Kinetic resolution, Methodology, Ruthenium, Transition Metal | Leave a Comment »

KR by NHC

Posted by naturalproductman on July 24, 2013

Kenichi Yamada and co-workers at Kyoto University have reported in JACS on a kinetic resolution approach to resolve 1,2-diols.
NHC

JACS paper

Posted in Asymmetric, Kinetic resolution, Methodology, Organocatalytic | Leave a Comment »

DYKAT

Posted by naturalproductman on May 9, 2013

Jeffrey Johnson and co-workers at UNC have reported in Org Lett on a dynamic kinetic resolution.

KR

OL paper

Posted in Asymmetric, Friedel-Crafts, Kinetic resolution, Methodology, Named Reactions | Leave a Comment »

Determination of stereochemistry on a small scale

Posted by naturalproductman on December 5, 2012

Scptt Rychnovsky and co-workers have reported in JACS on a clever way to determine the stereochemical configuration of a primary amine by using mass spectrometry.  This may be useful when you only have a small amount of material.

chirality

JACS paper

Posted in Asymmetric, Kinetic resolution, Mass Spectrometry, Methodology | Leave a Comment »

Deracemization via ketene dithioacetal intermediate

Posted by naturalproductman on October 30, 2012

Benjamin List and colleague have reported in JACS on a deracemization reaction taking advantage of a ketene-dithioacetal intermediate.

ketene

JACS paper

Posted in Asymmetric, Kinetic resolution, Methodology, Organocatalytic | Leave a Comment »

 
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