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Archive for the ‘Kinetic resolution’ Category

Pd-catalyzed DKR

Posted by naturalproductman on April 16, 2015

Xinjun Luan and co-workers have reported in JACS on a palladium catalyzed dynamic kinetic resolution of biaryls to spirocyclic centers.

spirocycle

JACS paper

Posted in Cascade Reactions, Kinetic resolution, Methodology, Palladium, Transition Metal | Leave a Comment »

Another thing to add to the dynamic kinetic resolution book

Posted by naturalproductman on April 12, 2015

Yu Zhao and co-workers from the National University of Singapore have reported in JACS on an iridium catalyzed dynamic kinetic resolution of a diastereomeric mixture of alcohols to chiral amines using a phosphoric acid ligand.

amine

JACS paper

Posted in Iridium, Kinetic resolution, Transition Metal | Leave a Comment »

Posted by naturalproductman on January 18, 2015

Masahiro Terada and co-workers from Tohoku University have reported in JACS on a kinetic resolution approach to accessing chiral amino-alcohols using a chiral phosphoric acid to form an acetal.

phosphoric

JACS paper

Posted in Asymmetric, Kinetic resolution, Methodology | Leave a Comment »

Posted by naturalproductman on March 7, 2014

Tsutomu Katsuki and co-workers at Kyushu University have reported on a ruthenium catalyzed kinetic resolution of racemic secondary alcohols via oxidation.

ruthenium

ACIE paper

Posted in Asymmetric, Kinetic resolution, Methodology, Ruthenium, Transition Metal | Leave a Comment »

KR by NHC

Posted by naturalproductman on July 24, 2013

Kenichi Yamada and co-workers at Kyoto University have reported in JACS on a kinetic resolution approach to resolve 1,2-diols.
NHC

JACS paper

Posted in Asymmetric, Kinetic resolution, Methodology, Organocatalytic | Leave a Comment »

DYKAT

Posted by naturalproductman on May 9, 2013

Jeffrey Johnson and co-workers at UNC have reported in Org Lett on a dynamic kinetic resolution.

KR

OL paper

Posted in Asymmetric, Friedel-Crafts, Kinetic resolution, Methodology, Named Reactions | Leave a Comment »

Determination of stereochemistry on a small scale

Posted by naturalproductman on December 5, 2012

Scptt Rychnovsky and co-workers have reported in JACS on a clever way to determine the stereochemical configuration of a primary amine by using mass spectrometry.  This may be useful when you only have a small amount of material.

chirality

JACS paper

Posted in Asymmetric, Kinetic resolution, Mass Spectrometry, Methodology | Leave a Comment »

Deracemization via ketene dithioacetal intermediate

Posted by naturalproductman on October 30, 2012

Benjamin List and colleague have reported in JACS on a deracemization reaction taking advantage of a ketene-dithioacetal intermediate.

ketene

JACS paper

Posted in Asymmetric, Kinetic resolution, Methodology, Organocatalytic | Leave a Comment »

DKR of alpha-keto esters

Posted by naturalproductman on April 19, 2012

Jeffrey Johnson and co-workers from UNC have reported in JACS on a dynamic kinetic resolution of substituted alpha-keto esters.

alpha keto ester

JACS paper

Posted in Asymmetric, Cascade Reactions, Kinetic resolution, Methodology | Leave a Comment »

Kinetic resolution with amidine

Posted by naturalproductman on February 10, 2012

Vladimir Birman and co-workers at Washington University in St. Louis have reported in JOC on a kinetic resolution of secondary alcohols using an amidine catalyst.

KR
JOC paper

Posted in Asymmetric, Kinetic resolution, Methodology | Leave a Comment »

 
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