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Archive for the ‘Multi-Component Coupling’ Category

This reaction involves combining more than two fragments together to form one large fragment.

A3 reaction with thiourea cocatalyst

Posted by naturalproductman on April 12, 2015

Daniel Seidel and co-worker at Rutgers have reported in JACS on an asymmetric A3 reaction using a thiourea cocatalyst.

A3

JACS paper

Posted in Cascade Reactions, Copper, Methodology, Multi-Component Coupling, Organocatalytic, Transition Metal | Leave a Comment »

Propargylamines via multi-component approach

Posted by naturalproductman on November 29, 2014

Zhihua Sun and co-workers from the Shanghai University of Engineering Science have reported in JOC on a multicomponent approach to substituted propargylamines.

MCC

JOC paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling | Leave a Comment »

Multi-component coupling with cobalt

Posted by naturalproductman on November 28, 2014

Xiaobing Wan and co-workers from Soochow University have reported in ACIE on a multi-component coupling approach to access β-Ester-γ-amino ketones.

tbhp

ACIE paper

Posted in Cascade Reactions, Cobalt, Methodology, Multi-Component Coupling, Transition Metal | Leave a Comment »

Alpha-arylation/N-Alkylation

Posted by naturalproductman on December 17, 2013

Daniel Seidel and co-workers at Rutgers have reported in Organic Letters on an alpha-arylation/N-alkylation reaction.

N-alkylation

OL paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling | Leave a Comment »

Posted by naturalproductman on September 5, 2013

Masaya Sawamura and co-workers published in ACIE on a copper catalyzed three component coupling between an alkyl borane, tributyltin methoxide, and an alkynoate.

tin

ACIE paper

Posted in Copper, Methodology, Multi-Component Coupling, Transition Metal | Leave a Comment »

Benzyne intermediate

Posted by naturalproductman on August 30, 2013

Akkattu Biju and co-workers from CSIR have reported in Org Lett on a multi-component reaction involving a benzyne intermediate.

benzyne

OL paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling | Leave a Comment »

5 component cascade

Posted by naturalproductman on July 10, 2013

Jonathan George and co-workers from the University of Adeleide have reported in Org Lett on a five component cascade to synthesize penilactone A and B.

5

OL Paper

Posted in Methodology, Multi-Component Coupling, Total Synthesis | Leave a Comment »

Pd-catalyzed 3 component coupling

Posted by naturalproductman on March 13, 2013

Matthew Sigman and colleague at the University of Utah have reported in JACS on a palladium catalyzed three component coupling reaction.

three

JACS paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling, Palladium, Transition Metal | Leave a Comment »

Multi-component approach to guajadial B

Posted by naturalproductman on November 21, 2012

Looking at this molecule, one would never think that you can mix three things, a penta-substituted benzene ring, benzaldehyde and humulene, and obtain the final compound, guajadial! Ji-Kai Liu and co-workers at the Kunming Institute of Botany did such a thing!

MCC
OL paper

Posted in Biosynthesis, Cascade Reactions, Meroterpenoids, Methodology, Multi-Component Coupling, One pot, Total Synthesis | Leave a Comment »

Titanium mediated Ugi reaction

Posted by naturalproductman on September 7, 2012

Marco Ciufolini and co-workers have reported in Organic Letters on an Ugi reaction.

Ugi

OL paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling, Named Reactions, Titanium, Transition Metal, Ugi | Leave a Comment »

 
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