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Archive for the ‘Multi-Component Coupling’ Category

This reaction involves combining more than two fragments together to form one large fragment.

Asymmetric Passerini reaction

Posted by naturalproductman on November 3, 2015

When I saw the Passerini reaction in the title, I thought of the use of an Ugi reaction in the synthesis of dysibetaine by the Kobayashi group. Bin Tan and co-workers at South University of Science and Technology in China have reported in JACS on a phosphoric acid catalyzed Passerini reaction.

Passerini

JACS paper

Posted in Asymmetric, Methodology, Multi-Component Coupling, Organocatalytic | Leave a Comment »

Ustiloxin D synthesis

Posted by naturalproductman on October 28, 2015

Craig Hutton and co-workers from University of Melbourne have reported in JOC on a synthesis of ustiloxin using an ammonia-Ugi reaction.
Ugi

JOC paper

Posted in Multi-Component Coupling, Named Reactions, Peptides, Total Synthesis | Leave a Comment »

Pyridimidine through multi-component coupling

Posted by naturalproductman on October 1, 2015

Rhett Kempe and co-workers from Universität Bayreuth have reported in JACS on an iridium catalyzed multi-component approach to synthesize pyrimidines from an amidine and three different alcohols.

pyrimidine

JACS paper

Posted in Iridium, Methodology, Multi-Component Coupling, Transition Metal | Leave a Comment »

Secu’amamine A synthesis

Posted by naturalproductman on August 21, 2015

Amos Smith and colleague have reported in Organic Letters on the synthesis of secu’amamine A.
secu'amamine A
OL paper

Posted in Alkaloids, Methodology, Multi-Component Coupling, Total Synthesis | Leave a Comment »

Cannizzaro cascade

Posted by naturalproductman on July 30, 2015

Simon Woodward and co-workers have reported in ACIE on a Cannizzaro cascade reaction using tert-butyl lithium.
cascade
ACIE paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling | Leave a Comment »

A3 reaction with thiourea cocatalyst

Posted by naturalproductman on April 12, 2015

Daniel Seidel and co-worker at Rutgers have reported in JACS on an asymmetric A3 reaction using a thiourea cocatalyst.

A3

JACS paper

Posted in Cascade Reactions, Copper, Methodology, Multi-Component Coupling, Organocatalytic, Transition Metal | Leave a Comment »

Propargylamines via multi-component approach

Posted by naturalproductman on November 29, 2014

Zhihua Sun and co-workers from the Shanghai University of Engineering Science have reported in JOC on a multicomponent approach to substituted propargylamines.

MCC

JOC paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling | Leave a Comment »

Multi-component coupling with cobalt

Posted by naturalproductman on November 28, 2014

Xiaobing Wan and co-workers from Soochow University have reported in ACIE on a multi-component coupling approach to access β-Ester-γ-amino ketones.

tbhp

ACIE paper

Posted in Cascade Reactions, Cobalt, Methodology, Multi-Component Coupling, Transition Metal | Leave a Comment »

Alpha-arylation/N-Alkylation

Posted by naturalproductman on December 17, 2013

Daniel Seidel and co-workers at Rutgers have reported in Organic Letters on an alpha-arylation/N-alkylation reaction.

N-alkylation

OL paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling | Leave a Comment »

Posted by naturalproductman on September 5, 2013

Masaya Sawamura and co-workers published in ACIE on a copper catalyzed three component coupling between an alkyl borane, tributyltin methoxide, and an alkynoate.

tin

ACIE paper

Posted in Copper, Methodology, Multi-Component Coupling, Transition Metal | Leave a Comment »

 
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