Guangbin Dong and colleague at UT Austin have reported in ACIE on the synthesis of cycloinumakiol through a rhodium catalyzed cascade reaction that forms the tetracyclic ring structure of the compound.
Posted by naturalproductman on November 21, 2012
Looking at this molecule, one would never think that you can mix three things, a penta-substituted benzene ring, benzaldehyde and humulene, and obtain the final compound, guajadial! Ji-Kai Liu and co-workers at the Kunming Institute of Botany did such a thing!
Posted by naturalproductman on April 25, 2012
Zhigang Weng and co-workers from Shenzhen University have reported in Tetrahedron on a synthesis of angelone. The highlight is the cascade reaction forming the final product.
Posted by naturalproductman on October 19, 2011
Istvan Marko and co-workers at Université catholique de Louvain in Belgium have reported in Tetrahedron on a nice synthesis of Telaprevir using an oxaziridine and a lithium amide to functionalize an alkene.
Posted by naturalproductman on January 27, 2011
Jinxing Ye and co-workers at East China University of Science and Technology have published on a one pot organocatalytic reaction to form oxazines. I guess one pot reactions are all the craze now: