Naturalproductman’s Blog

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Archive for the ‘Methodology’ Category

Diyne to cyclohexenone

Posted by naturalproductman on July 31, 2016

Radomir Salicic and co-workers from the University of Belgrade have reported in Organic Letters on a gold catalyzed cascade cyclization of a diyne.

 

OL paper

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Posted in Cascade Reactions, Gold, Methodology, Transition Metal | Leave a Comment »

Enol triflates to alkynes

Posted by naturalproductman on July 31, 2016

Doug Frantz and colleague have reported in Organic Letters on a Pd-catalyzed conversion of a vinyl triflate to a disubstituted alkyne.

 

OL paper

Posted in Cascade Reactions, Methodology, Palladium, Transition Metal | Leave a Comment »

From vinyl azides to alpha-fluoroketones

Posted by naturalproductman on July 31, 2016

Feng Liu and colleague at Soochow University reported in Organic Letters on using Selectfluor to convert vinyl azides to alpha-fluoroketones.

 

OL paper

Posted in Cascade Reactions, Mechanistic, Methodology | Leave a Comment »

Chiral Anion Phase Transfer (CAPT)

Posted by naturalproductman on July 30, 2016

Dean Toste and co-workers have reported in JACS on the enantioselective synthesis of flavonoids using CAPT.

 

JACS paper

Posted in Asymmetric, Polyketides, Total Synthesis | Leave a Comment »

Palladium – olefin/insertion cascade

Posted by naturalproductman on July 4, 2016

Vellaisamy Sridharan and co-workers from SASTRA University have reported in Organic Letters on a palladium catalyzed hydration olefin-insertion cascade.

 

OL paper

Posted in Cascade Reactions, Methodology, Palladium | Leave a Comment »

Siloxydifluorocyclopropanes open

Posted by naturalproductman on July 4, 2016

Mang Wang and co-workers from Northeast Normal University have reported in Organic Letters on a ring opening reaction of siloxy difluorocyclopropane to access difluorocyclopentenones.

 

OL paper

Posted in Ring Opening | Leave a Comment »

Sulfur ylides with copper allenylidenes

Posted by naturalproductman on July 4, 2016

Wen-Jing Xiao and co-workers from Central China Normal University have reported in JACS on an asymmetric [4+1] reaction between a copper allenylidene and sulfur ylide.

 

JACS paper

Posted in Asymmetric, Carbene, Copper, Methodology, Transition Metal | Leave a Comment »

Chiral allenes via Mukaiyama-Aldol

Posted by naturalproductman on July 4, 2016

Benjamin List and co-workers at Max-Planck-Institut für Kohlenforschung reported in ACIE on a Mukaiyama-Aldol approach to access axially chiral allenes.
ACIE paper

Posted in Allenes, Methodology, Mukaiyama, Named Reactions, Organocatalytic | Leave a Comment »

Siloxydiene meets a 1,3-dicarbonyl

Posted by naturalproductman on June 16, 2016

Justin Mohr and co-workers at the University of Illinois in Chicago have reported in Organic Letters on a Mn-promoted oxidative coupling between a siloxydiene and a 1,3-dicarbonyl. They use 2.25 mol equivalents of Mn though so there’s room to make it better?

 

OL paper

Posted in Manganese, Transition Metal | Leave a Comment »

Communensin F synthesis

Posted by naturalproductman on June 16, 2016

Mohammed Movassaghi and co-workers reported in JACS on the synthesis of communensin F.

 

JACS paper

Posted in Alkaloids, Methodology, Radical Chemistry, Total Synthesis | Leave a Comment »