Naturalproductman’s Blog

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Archive for the ‘Methodology’ Category

Transamination reaction

Posted by naturalproductman on August 22, 2016

Here’s a transamination reaction reported in JACS. Normally pyridoxal-phosphate containing enzymes do this in nature but this is the biomimetic approach.

 

JACS paper

Posted in Cascade Reactions, Methodology, Organocatalytic | Leave a Comment »

Triiodide-mediated C-H amination

Posted by naturalproductman on July 31, 2016

David Nagib and co-workers from the Ohio State University have reported in ACIE on a triiodide mediated C-H amination reaction.

 

ACIE paper

Posted in C-H activation, Hypervalent Iodine, Methodology | Leave a Comment »

Amidation-C-H activation cascade

Posted by naturalproductman on July 31, 2016

Santhosh Mhaske and colleague at CSIR have reported in Organic Letters on a palladium catalyzed amidation-C-H activation cascade.
OL paper

Posted in Cascade Reactions, Methodology, Palladium, Transition Metal | Leave a Comment »

Diyne to cyclohexenone

Posted by naturalproductman on July 31, 2016

Radomir Salicic and co-workers from the University of Belgrade have reported in Organic Letters on a gold catalyzed cascade cyclization of a diyne.

 

OL paper

Posted in Cascade Reactions, Gold, Methodology, Transition Metal | Leave a Comment »

Enol triflates to alkynes

Posted by naturalproductman on July 31, 2016

Doug Frantz and colleague have reported in Organic Letters on a Pd-catalyzed conversion of a vinyl triflate to a disubstituted alkyne.

 

OL paper

Posted in Cascade Reactions, Methodology, Palladium, Transition Metal | Leave a Comment »

From vinyl azides to alpha-fluoroketones

Posted by naturalproductman on July 31, 2016

Feng Liu and colleague at Soochow University reported in Organic Letters on using Selectfluor to convert vinyl azides to alpha-fluoroketones.

 

OL paper

Posted in Cascade Reactions, Mechanistic, Methodology | Leave a Comment »

Chiral Anion Phase Transfer (CAPT)

Posted by naturalproductman on July 30, 2016

Dean Toste and co-workers have reported in JACS on the enantioselective synthesis of flavonoids using CAPT.

 

JACS paper

Posted in Asymmetric, Polyketides, Total Synthesis | Leave a Comment »

Palladium – olefin/insertion cascade

Posted by naturalproductman on July 4, 2016

Vellaisamy Sridharan and co-workers from SASTRA University have reported in Organic Letters on a palladium catalyzed hydration olefin-insertion cascade.

 

OL paper

Posted in Cascade Reactions, Methodology, Palladium | Leave a Comment »

Siloxydifluorocyclopropanes open

Posted by naturalproductman on July 4, 2016

Mang Wang and co-workers from Northeast Normal University have reported in Organic Letters on a ring opening reaction of siloxy difluorocyclopropane to access difluorocyclopentenones.

 

OL paper

Posted in Ring Opening | Leave a Comment »

Sulfur ylides with copper allenylidenes

Posted by naturalproductman on July 4, 2016

Wen-Jing Xiao and co-workers from Central China Normal University have reported in JACS on an asymmetric [4+1] reaction between a copper allenylidene and sulfur ylide.

 

JACS paper

Posted in Asymmetric, Carbene, Copper, Methodology, Transition Metal | Leave a Comment »