Guangbin Dong and colleague have reported in JACS on an intramolecular coupling between cyclobutanones and allenes.
Archive for the ‘Ring forming’ Category
This reaction involves different ways to form rings from acyclic precursors.
Chlorinated tetrahydropyran opening
Posted by naturalproductman on August 5, 2015
Elizabeth Jarvo and co-workers at UC Irvine have reported in JACS on a cyclopropane ring formation from a chlorinated tetrahydropyran.
Posted in Cascade Reactions, Methodology, Ring forming | Leave a Comment »
Sn2 prime with trichloroacetimidates
Posted by naturalproductman on May 28, 2015
At first look of the abstract figure I thought this was an Overman rearrangement paper but no, trichloroacetimidates are also good leaving groups for Sn2 prime reactions.
Posted in Cascade Reactions, Methodology, Ring forming, Sn2 prime | Leave a Comment »
Cyclobutenone ring expansion
Posted by naturalproductman on August 20, 2014
Guangbin Dong and colleague at UT Austin have reported in ACIE on the synthesis of cycloinumakiol through a rhodium catalyzed cascade reaction that forms the tetracyclic ring structure of the compound.
Posted in Methodology, One pot, Rhodium, Ring expansion, Ring forming, Ring Opening, Total Synthesis, Transition Metal | Leave a Comment »
Z-selective olefin metathesis
Posted by naturalproductman on August 20, 2014
Robert Grubbs and co-workers have reported in JACS on factors that influence Z-selective olefin metathesis.
Posted in Metathesis, Methodology, Ring forming, Ruthenium, Transition Metal | Leave a Comment »
Salvileucalin C synthesis
Posted by naturalproductman on June 6, 2014
Hanfeng Ding and co-workers from Zhejiang University have reported in Organic Letters on the synthesis of salvileucalin C. I thought of Sarah Reisman’s work but she of course made salvileucalin B. By the way, I noticed that Sarah Reisman was promoted directly from assistant prof to prof at Caltech so kudos to her.
Posted in Methodology, Ring forming, Total Synthesis, Transannular | Leave a Comment »
Andrastin C synthesis
Posted by naturalproductman on November 19, 2012
Masahiro Toyota and co-workers from Tohoku University have reported in JOC on the synthesis of andrastin C.
Posted in Cascade Reactions, Methodology, Ring forming, Steroids | Leave a Comment »
Rhodium catalyzed reaction
Posted by naturalproductman on November 6, 2012
P. Andrew Evans (University of Liverpool) and Mu-Hyun Baik (Indiana University) and co-workers have published in JACS on a mechanistic investigation of a rhodium catalyzed [3+2+1] cyclization. The Los Alamos LACVP basis set was used to represent rhodium.
Posted in Computational, DFT, Mechanistic, Methodology, Rhodium, Ring forming, Silver, Transition Metal | Leave a Comment »
FD-895 synthesis
Posted by naturalproductman on October 25, 2012
Michael Burkart and James J. La Clair and colleagues at UCSD have reported in Org Lett on the synthesis of
Posted in Macrolides, Metathesis, Methodology, Polyketides, Ring forming, Ruthenium, Structural Reassignment, Transition Metal | Leave a Comment »
Cyclization through fluorination
Posted by naturalproductman on October 25, 2012
Guosheng Liu and colleague at the Chinese Academy of Science have reported in Org Lett on a fluorination reaction that involves ring formation.
Posted in Cascade Reactions, Methodology, Ring forming | Leave a Comment »
