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Archive for the ‘Transition Metal’ Category

Reactions involving transition metals

Iron-catalyzed cross coupling between Grignard reagents and enol carbamates

Posted by naturalproductman on May 3, 2016

Doug Frantz and co-workers from UTSA have reported in ACIE on an iron-catalyzed cross-coupling reaction between enol carbamates and Grignard reagents.

 

ACIE paper

Posted in cross coupling, Iron, Methodology, Transition Metal | Leave a Comment »

Propargylic benzoate to allene

Posted by naturalproductman on April 19, 2016

Erick Carreira and colleague have reported in Organic Letters on a rhodium catalyzed synthesis of chiral allenes from propargylic benzoates.

 

OL paper

Posted in Allenes, Methodology, Rhodium, Transition Metal | Leave a Comment »

Desymmetrization with proline and Pd

Posted by naturalproductman on April 19, 2016

Yi-Xia Jia and co-workers from Zhejiang University have reported in JACS on an intramolecular desymmetrization by a Heck reaction.

 

JACS paper

Posted in Desymmetrization, Heck, Methodology, Mizoroki-Heck, Organocatalytic, Palladium, Transition Metal | Leave a Comment »

Palladium Carbenes

Posted by naturalproductman on April 19, 2016

Daniel Sole and co-workers at Universidad Complutense de Madrid have reported in ACIE on the generation of palladium carbenoids from diazo precursors to effect an intramolecular C-H insertion.

 

ACIE paper

Posted in Carbene, Methodology, Palladium | Leave a Comment »

Enyne metathesis – a mechanistic investigation

Posted by naturalproductman on April 14, 2016

Steven Diver and co-workers at SUNY Buffalo have reported in JACS on a mechanistic study of enyne metathesis using Hoveyda catalyst and Grubbs 2nd generation catalyst.

 

JACS paper

Posted in Kinetics, Mechanistic, Methodology, Ruthenium, Transition Metal | Leave a Comment »

Cyclobutenes from alkynes and silyl enol ethers

Posted by naturalproductman on April 14, 2016

Xiaoming Feng and co-workers from Sichuan University have reported in ACIE on a Zn-catalyzed [2+2] reaction between alkynones and cyclic silyl enol ethers.

 

ACIE paper

Posted in Asymmetric, Cascade Reactions, Methodology, Transition Metal, Zinc, [2+2] | Leave a Comment »

Cyclopropanation ring expansion

Posted by naturalproductman on April 8, 2016

Martin Trmblay and co-workers from Infinity Pharmaceuticals have reported in Organic Process Research & Development on a scalable 6 to 7 membered ring expansion towards a hedgehog antagonist. When I looked at the structure it reminded me of cyclopamine.

 

ORPD paper

Posted in Cascade Reactions, Methodology, Ring expansion, Zinc | Leave a Comment »

Rhodium catalyzed decarboxylative coupling

Posted by naturalproductman on April 6, 2016

Bernhard Breit and co-workers reported in Chemical Communications on a rhodium catalyzed decarboxylative addition of beta-ketoacids to alkynes.

 

Chem Comm paper

Posted in Methodology, Rhodium, Transition Metal | Leave a Comment »

C-H silylation

Posted by naturalproductman on April 6, 2016

L.T. Pilarski and co-workers from the University of Uppsala in Sweden have reported in Chemical Communications on a ruthenium catalyzed C-H silylation.

 

Chem Comm paper

Posted in C-H activation, Methodology, Ruthenium, Transition Metal | Leave a Comment »

Deoxygenation of primary alcohols over secondary alcohols

Posted by naturalproductman on April 5, 2016

Chao-Jun Li and colleague from McGill University reported in JACS on a ruthenium catalyzed primary alcohol deoxygenation reaction. This reaction is selective for primary alcohols over secondary alcohols.

*Note spelling error “MACHANISM” on page 6

JACS paper

Posted in Methodology, Ruthenium, Transition Metal | Leave a Comment »

 
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