Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Gold’ Category

Diyne to cyclohexenone

Posted by naturalproductman on July 31, 2016

Radomir Salicic and co-workers from the University of Belgrade have reported in Organic Letters on a gold catalyzed cascade cyclization of a diyne.

 

OL paper

Posted in Cascade Reactions, Gold, Methodology, Transition Metal | Leave a Comment »

Cannabimovone synthesis

Posted by naturalproductman on May 29, 2016

Antonio Echavarran and co-workers from ICIQ have reported in ACIE on the synthesis of cannabimovone.

 

ACIE paper

Posted in alkyne, Cascade Reactions, Gold, Methodology, Structural Reassignment, Total Synthesis | Leave a Comment »

Rh- and Au- Cooperative Catalysis

Posted by naturalproductman on April 5, 2016

Here’s a neat cascade reaction from Sreenivas Katukojvala and colleague at Indian Institute of Science Education & Research involving the use of rhodium, gold, and diphenylphosphate to access 1,4-oxazines from enaldiazo ketones and N-propargyl anilines.

 

ACIE paper

Posted in Cascade Reactions, Cooperative Catalysis, Gold, Methodology, Rhodium, Transition Metal | Leave a Comment »

Hydroxygardnerine, Hydroxygardnutine, Gardnerine, (E)-16-epi-Normacusine B, and Koumine syntheses

Posted by naturalproductman on April 4, 2016

Hiromitsu Takayama and co-workers from Chiba University have reported in Organic Letters on the syntheses of some indole alkaloids using a gold catalyzed 6-exo dig cyclization – which looks like a Conia-ene reaction.

 

OL paper

Posted in Alkaloids, Conia-Ene, Gold, Indoles, Named Reactions, Total Synthesis, Transition Metal | Leave a Comment »

Gold catalyzed photoredox chemistry

Posted by naturalproductman on February 3, 2016

Stephen Hashmi and co-workers have reported in ACIE on the use of a gold dimer catalyst with a diphenylphosphinomethane ligand to effect a difluoroalkylation reaction.

hashmi ACIE 2016.gif

ACIE paper

Posted in Gold, Light Mediated, Methodology, Radical Chemistry, Transition Metal | Leave a Comment »

Back to Back Method Papers: Allenamide + Aldehyde = alpha-Alkylation

Posted by naturalproductman on January 22, 2016

Fernando Lopez and co-workers at Universidad de Santiago de Compostela have reported in Chemical Communications on a gold/organocatalyst-cocatalyzed alpha alkylation of aldehydes. Interestingly Jose Gonzalez and co-workers at Universidad de Oviedo also reported in Chem Comm on a gold/organocatalyst reaction.

 

Chem Comm paper

 

Chem Comm paper 2

Posted in Allenes, Asymmetric, Cascade Reactions, Cooperative Catalysis, Gold, Methodology, Organocatalytic, Transition Metal | Leave a Comment »

Sufur ylide chemistry – intramolecular cyclopropanation

Posted by naturalproductman on May 28, 2015

Nuno Maulide and co-workers from the University of Vienna have reported in JOC on an intramolecular cyclopropanation from a sulfur slide precursor and what follows is a nice mechanistic investigation.

sulfur

JOC paper

Posted in Computational, DFT, Gold, Mechanistic, Methodology, Transition Metal | Leave a Comment »

Methylene transfer

Posted by naturalproductman on May 2, 2015

Itaru Nakamura and co-workers from Tohoku University have reported in ACIE on a gold catalyzed methylene transfer sequence to access isoxazolines.

methylene

ACIE paper

Posted in Cascade Reactions, Gold, Methodology, Transition Metal | Leave a Comment »

Gold catalyzed spiroketalization

Posted by naturalproductman on April 12, 2015

Aaron Aponick and co-workers from the University of Florida have used a trimethylphosphine additive to improve the gold catalyzed spiroketalization for spirastrellolide.

gold

OL paper

Posted in Diastereoselective, Gold, Methodology, Regioselective, Transition Metal | Leave a Comment »

Gold cascade

Posted by naturalproductman on March 5, 2015

Dean Toste and co-workers have reported in JACS on a gold catalyzed Rautenstrauch cascade reaction.

gold

JACS paper

Posted in Cascade Reactions, Gold, Methodology, Named Reactions, Rautenstrauch rearrangement, Transition Metal | Leave a Comment »

 
Follow

Get every new post delivered to your Inbox.

Join 84 other followers