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Archive for the ‘Named Reactions’ Category

Towards halichondrins

Posted by naturalproductman on May 12, 2015

I would call the vinyl halide coupling reaction with an aldehyde using chromium/nickel combination a Nozaki Hiyama Kishi coupling, but maybe because the author is one of the people in the named reaction, it wasn’t mentioned in the paper as the “NHK reaction”, but rather, a Ni/Cr-mediated reaction.

halichondrin

JACS paper

JACS paper 2

Posted in Chromium, cross coupling, Methodology, Named Reactions, Nickel, Polyketides, Total Synthesis | Leave a Comment »

Domino acylation Diels-Alder

Posted by naturalproductman on May 2, 2015

Jeffrey Aube (University of Kansas) and Dean Tantillo (UC Davis) have teamed up to study the mechanism of a domino acylation-Diels Alder reaction.

domino

OL paper

Posted in DFT, Diels-Alder, Mechanistic, Methodology, Named Reactions | Leave a Comment »

Hypervalent iodine towards lactams

Posted by naturalproductman on May 2, 2015

Antonio Herrera and co-workers from CSIC have reported in Organic Letters on a hypervalent iodine approach to access lactams from linear precursors.

OL paper

Posted in Hofmann–Löffler–Freytag-type, Hypervalent Iodine, Methodology, Named Reactions | Leave a Comment »

Reverse Claisen cascade

Posted by naturalproductman on April 16, 2015

Yongjia Shang and co-workers from Anhui Normal University have reported in JOC on an interesting iron catalyzed cascade reaction.

JOC paper

Posted in Cascade Reactions, Claisen rearrangement, Iron, Methodology, Sigmatropic Rearrangements, Transition Metal | Leave a Comment »

5,6-Dihydrocineromycin B synthesis

Posted by naturalproductman on April 16, 2015

Alois Furstner and co-workers have reported in ACIE on the synthesis of 5,6-dihydrocineromycin B.
lactone
ACIE paper

Posted in cross coupling, Macrolides, Named Reactions, Total Synthesis | Leave a Comment »

Reductive Heck reaction

Posted by naturalproductman on April 12, 2015

Yi-Xia Jia and co-workers have reported in JACS on an intramolecular Heck reaction.

Heck

JACS paper

Posted in Cascade Reactions, Heck, Methodology, Named Reactions | Leave a Comment »

Separating E vs. Z alkenes through pH

Posted by naturalproductman on April 12, 2015

Jinbo Hu and co-workers from SIOC have reported in JACS on a resolution of Julia-Kocienski olefination intermediates depending on the pH of the solution.

Julia

JACS paper

Posted in Methodology, Named Reactions | Leave a Comment »

Rocaglamide synthesis

Posted by naturalproductman on March 31, 2015

Marcus Tius and colleague have reported in ACIE on the asymmetric synthesis of rocaglamide.
rocaglamide

ACIE paper

Posted in Asymmetric, Named Reactions, Nazarov cyclization, Total Synthesis | Leave a Comment »

Gold cascade

Posted by naturalproductman on March 5, 2015

Dean Toste and co-workers have reported in JACS on a gold catalyzed Rautenstrauch cascade reaction.

gold

JACS paper

Posted in Cascade Reactions, Gold, Methodology, Named Reactions, Rautenstrauch rearrangement, Transition Metal | Leave a Comment »

Cochliomycin synthesis via NHK

Posted by naturalproductman on November 29, 2014

Martin Banwell and co-workers at the Australian National University have reported in JOC on the synthesis of cochliomycins A and B.

cochliomycins

JOC paper

Posted in cross coupling, Macrolides, Metathesis, Methodology, Named Reactions, Polyketides, Total Synthesis | Leave a Comment »

 
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