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Archive for the ‘Eschenmoser-Tanabe fragmentation’ Category

Synthesis of Mersicarpine

Posted by naturalproductman on January 7, 2010

Fukuyama and co-workers at the University of Tokyo have recently reported on a synthesis of mersicarpine.  A highlight of the synthesis includes a coupling between a haloaniline with an alkyne to form the indole moiety.  In addition, the Eschenmoser-Tanabe fragmentation to afford the alkyne fragment was pretty neat.

JACS paper

Posted in Cascade Reactions, cross coupling, Eschenmoser-Tanabe fragmentation, Methodology, Named Reactions, Sonogashira, Transition Metal | Leave a Comment »