Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Julia-Kocienski’ Category

Polychlorinated natural product

Posted by naturalproductman on July 12, 2011

Erick Carreira and co-workers have reported in ACIEE on their synthesis of this lipid that contains eleven chlorines.


ACIEE paper

Posted in Julia-Kocienski, Martin sulfurane, Methodology, Named Reactions, Named Reagents | Leave a Comment »

Towards Chlorahololide A

Posted by naturalproductman on February 3, 2010

Fa-Jun Nan and co-worker at the Chinese Academy of Sciences have recently published in Tetrahedron Letters on their progress towards chlorahololide A.  An interesting structure in their route can be found in a Grignard addition of an bromo-magnesium bromo vinyl group that adds onto an aldehyde to ultimately form a bromo-butenolide.

chlorahololide A

TL paper

Posted in Cascade Reactions, cross coupling, Heck, Julia-Kocienski, Methodology, Named Reactions, Palladium, Ring forming, Sesquiterpenes, Transition Metal | Leave a Comment »

Exiguolide Synthesis

Posted by naturalproductman on January 12, 2010

Exiguolide, a macrolide that specifically inhibits gamete fertilization of sea urchins but not the embryogenesis of the fertilized egg, was synthesized by Haruhiko Fuwa and co-workers at Tohoku University.


OL paper

Posted in cross coupling, Julia-Kocienski, Macrocycles, Macrolides, Methodology, Polyenes, Suzuki-Miyaura, Transition Metal, Yamaguchi macrolactonization | Leave a Comment »