Gracilamine synthesis

Shuanhu Gao and co-workers at East China Normal University have reported in ACIE on the synthesis of gracilamine.

ACIE paper

 

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Virosine A synthesis

Guillame Belanger and co-workers from the Univerite de Sherbrooke in Canada have reported in JOC on the synthesis of virosine A.

JOC paper

Breaking the C-C triple bond

Igor Alabugin and co-workers from Florida State have reported in JOC on a double Michael reaction that cleaves the C-C triple bond of an alkynone.

JOC paper

Pyrroles from Imines and Alkynes

Darren Dixon and co-workers have reported in Chemical Communications on a gold catalyzed approach to form 2,5-disubstituted pyrroles.

 

Chem Comm paper

Lycoflexine Synthesis

Johann Mulzer and co-workers at the University of Vienna have published in JACS on a total synthesis of lycoflexine where the key reaction is an enynene ring closing metathesis reaction.

JACS paper

Fastigiatine

Matthew Shair and co-worker have published in JACS on the total synthesis of fastigiatine.  The key reactions involve a formal [3+3] reaction and a transannular Mannich reaction.

JACS paper

Actinophyllic Acid Synthesis

Larry Overman and co-workers have recently published on the synthesis of actinophyllic acid where the key reaction was the aza-Cope/Mannich reaction.

JACS paper

Michael to Mannich

Hanming Huang and co-workers at the Chinese Academy of Sciences have recently published in ACIEE on a cascade Michael-Mannich reaction.

ACIEE paper

Fast Access to Euphococcinine

Franklin Davis and co-worker at Temple University have recently published in Organic Letters on a bi-cyclization using simple acid and heat to furnish the alkaloid, euphococcinine.

OL paper

Vinylogous Mannich Reaction

Here’s a vinylogous Mannich reaction reported by Christoph Schneider and co-workers at Universität Leipzig in Germany.  They used a chiral Bronstead acid – a BINOL based phosphoric acid.

Chemistry a European Journal paper