Shuanhu Gao and co-workers at East China Normal University have reported in ACIE on the synthesis of gracilamine.
Posted by naturalproductman on July 12, 2014
Shuanhu Gao and co-workers at East China Normal University have reported in ACIE on the synthesis of gracilamine.
Posted in Alkaloids, Mannich, Methodology, Michael, Named Reactions, Nazarov cyclization, Total Synthesis | Leave a Comment »
Posted by naturalproductman on March 30, 2012
Guillame Belanger and co-workers from the Univerite de Sherbrooke in Canada have reported in JOC on the synthesis of virosine A.
Posted in Alkaloids, Asymmetric, Mannich, Methodology, Named Reactions, Vilsmeier-Haack | Leave a Comment »
Posted by naturalproductman on August 22, 2011
Igor Alabugin and co-workers from Florida State have reported in JOC on a double Michael reaction that cleaves the C-C triple bond of an alkynone.
Posted in C-C Bond Breaking, Cascade Reactions, Mannich, Methodology, Michael, Named Reactions, Pericyclic reactions, Sigmatropic Rearrangements | Leave a Comment »
Posted by naturalproductman on June 22, 2010
Matthew Shair and co-worker have published in JACS on the total synthesis of fastigiatine. The key reactions involve a formal [3+3] reaction and a transannular Mannich reaction.
Posted in Alkaloids, Cascade Reactions, Conjugate Additions, Mannich, Methodology, Named Reactions | Leave a Comment »
Posted by naturalproductman on March 10, 2010
Larry Overman and co-workers have recently published on the synthesis of actinophyllic acid where the key reaction was the aza-Cope/Mannich reaction.
Posted in Alkaloids, Asymmetric, Aza-Cope rearrangement, Mannich, Methodology, Named Reactions | Leave a Comment »
Posted by naturalproductman on March 10, 2010
Hanming Huang and co-workers at the Chinese Academy of Sciences have recently published in ACIEE on a cascade Michael-Mannich reaction.
Posted in Cascade Reactions, Mannich, Methodology, Michael, Multi-Component Coupling, Named Reactions | Leave a Comment »
Posted by naturalproductman on January 24, 2010
Franklin Davis and co-worker at Temple University have recently published in Organic Letters on a bi-cyclization using simple acid and heat to furnish the alkaloid, euphococcinine.
Posted in Alkaloids, Cascade Reactions, Mannich, Methodology, Named Reactions, Ring forming | Leave a Comment »
Posted by naturalproductman on January 24, 2010
Here’s a vinylogous Mannich reaction reported by Christoph Schneider and co-workers at Universität Leipzig in Germany. They used a chiral Bronstead acid – a BINOL based phosphoric acid.
Posted in Cascade Reactions, Mannich, Methodology, Multi-Component Coupling, Named Reactions, Organocatalytic | Leave a Comment »