Posted by naturalproductman on September 15, 2011
Masahisa Nakada and co-workers have reported in ACIEE on a synthesis of ophiobolin where the seven membered ring was accessed via a ring closing metathesis.
Posted in Cancer, Cascade Reactions, melanoma, Metathesis, Methodology, Named Reactions, Reformatsky, Ring forming, Ruthenium, Sesquiterpenoids, Seven-Membered Rings, Transition Metal | Leave a Comment »
Posted by naturalproductman on November 19, 2010
Jeffrey Johnson and co-workers at UNC have published in JACS on a Refoormatzky-Claisen condensation cascade reaction where the second enolate generated opens a beta-lactone.
Posted in Cascade Reactions, Claisen condensation, Methodology, Multi-Component Coupling, Named Reactions, Reformatsky, Ring Opening, Transition Metal, Zinc | Leave a Comment »