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Archive for the ‘Yamamoto rearrangement’ Category

Synthesis of Cymbodiacetal

Posted by naturalproductman on November 19, 2010

Christopher Hayes and co-workers from the University of Nottingham have published in JOC on the total synthesis of cymbodiacetal – a symmetrical molecule.  One of the key steps was the opening of a methylepoxide via Yamamoto rearrangement and a dimerization using a hetero-Diels-Alder transformation.



JOC paper

Posted in Cascade Reactions, Cycloaddition, Diels-Alder, Methodology, Named Reactions, Pericyclic reactions, Total Synthesis, Yamamoto rearrangement | Leave a Comment »