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Archive for the ‘Horner-Wadsworth-Emmons’ Category

Tormesol via Wittig

Posted by naturalproductman on November 21, 2011

Dongjoo Lee and co-workers at Dankook University have reported in Tetrahedron on the synthesis of tormesol.  The seven membered ring was acquired from a Horner-Wadsworth-Emmons reaction.


Tetrahedron paper

Posted in Horner-Wadsworth-Emmons, Methodology, Named Reactions, Named Reagents, Sesquiterpenoids, Total Synthesis, Wittig | Leave a Comment »

Exocyclic Methylenes

Posted by naturalproductman on November 28, 2010

Tomasz Janecki and co-workers have published in Synlett on a nice way to make subsituted 3-methylidene-chroman-2-ones (ie:  exocyclic methylenes) via 1,4-Grignard addition folowed by Wittig.

exocyclic methylene

Synlett paper

Posted in Conjugate Additions, Horner-Wadsworth-Emmons, Methodology, Named Reagents | Leave a Comment »