Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘New Setups’ Category

Measuring ee with NMR using a chiral counterion

Posted by naturalproductman on November 3, 2015

Hyunwoo Kim and colleague at KAIST have reported in JACS on the use of an aluminum reagent to determine the enantiomeric excess of amines and carboxylic acids.


JACS paper

Posted in Methodology, New Setups, NMR | Leave a Comment »

Correlating chemical shift of O-H proton with stereochemistry of masked 1,2-diols

Posted by naturalproductman on October 9, 2015

Jason Chen and co-workers from Iowa State have reported in JOC on the chemical shifts of an O-H proton of masked syn- and anti- 1,2-diols.


JOC paper

Posted in Computational, DFT, New Setups, NMR, Stereochemistry | Leave a Comment »

Cyclopropenones – a chemical biology tool

Posted by naturalproductman on August 7, 2015

Jennifer Prescher and colleague at UC Irvine have reported in JACS on the potential for using cyclopropenones to conjugate proteins.


JACS paper

Posted in Cascade Reactions, Chemical Biology, New Setups | Leave a Comment »

Machines in organic synthesis

Posted by naturalproductman on July 17, 2015

Steven Ley and co-workers reported in ACIE on a review of the different machines people use to make small molecules. I like the use of actual photographs of the equipment…


ACIE paper

Posted in Methodology, New Setups, New Types | Leave a Comment »

Hypodoratoxide structural revision through 13C-13C COSY

Posted by naturalproductman on April 16, 2015

Jeroen Disckschat and co-workers at Rheinische Friedrich-Wilhelms-Universität Bonn have reported in ACIE on a 13C-13C COSY method to elucidate the structure of hypodoratoxide.

ACIE paper

Posted in Methodology, New Setups, Structural Reassignment | Leave a Comment »

Efavirenz flow synthesis

Posted by naturalproductman on March 5, 2015

Peter Seeberger and co-workers at Max Planck Institute of Colloids and Interfaces have reported in ACIE on the flow synthesis of efavirenz.


ACIE paper

Posted in Flow, HIV, New Setups, Total Synthesis | Leave a Comment »

Modern day advances in the industry

Posted by naturalproductman on February 22, 2015

Jacketed reactor vessels, automated parallel reactor systems, flow chemistry, high-throughput parallel screening platforms, are all new types of reaction set ups advanced from our classical round bottom flask equipped with stir bars that industry chemists are using nowadays.  Check out this neat perspective in JOC by Stéphane Caron and Nicholas Thomson at Pfizer.

JOC paper

Posted in New Setups | Leave a Comment »

Circular dichroism approach to determine chirality

Posted by naturalproductman on February 22, 2015

Babak Borhan and co-workers have reported in ACIE on a way to determine remote chirality using the cotton effect and molecular tweezers.

molecular tweezers

ACIE paper

Posted in Methodology, Molecular tweezers, New Setups, Stereochemistry | Leave a Comment »


Posted by naturalproductman on November 27, 2014

Ehud Landau and co-workers at the University of Zurich have reported in ACIE on the use of a cyclopropane-containing lipid to crystallize membrane proteins.

ACIE paper

Posted in Chemical Biology, Lipids, New Setups, Unnatural Products | Leave a Comment »

Forazoline A

Posted by naturalproductman on September 10, 2014

I thought I was going to have some down time before I posted again, but I ran into this interesting isolation paper of forazoline A that is worth a gander from Tim Bugni’s lab in the University of Wisconsin. They used a 15N-13C HMQC technique to determine which carbon was bonded to which nitrogen, which is apparently the first time this technique was used for a natural product. Looks like a pretty large natural product (m/z 901.4205). They have an interesting looking 13C NMR spectrum of the natural product (13C-labeled) that have splitting patterns on basically all of the carbons of the natural product (and thus looks like a proton NMR).

ACIE paper

Posted in Antifungal, New Setups, New Types, NMR, Polyketides, Polythio Compounds, Thiazoles | Leave a Comment »