Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘NMR’ Category

A natural product binding protein

Posted by naturalproductman on February 12, 2016

Using NMR, David Jakeman and co-workers at Dalhousie University reported in JACS on a natural product binding protein, JadX.

 

JACS paper

Posted in New Techniques, NMR, Polyketides | Leave a Comment »

Measuring ee with NMR using a chiral counterion

Posted by naturalproductman on November 3, 2015

Hyunwoo Kim and colleague at KAIST have reported in JACS on the use of an aluminum reagent to determine the enantiomeric excess of amines and carboxylic acids.

ee

JACS paper

Posted in Methodology, New Setups, NMR | Leave a Comment »

Correlating chemical shift of O-H proton with stereochemistry of masked 1,2-diols

Posted by naturalproductman on October 9, 2015

Jason Chen and co-workers from Iowa State have reported in JOC on the chemical shifts of an O-H proton of masked syn- and anti- 1,2-diols.

NMR

JOC paper

Posted in Computational, DFT, New Setups, NMR, Stereochemistry | Leave a Comment »

Mollenynes B-E

Posted by naturalproductman on September 25, 2015

Tadeusz Molinski and co-workers have reported in JACS on the isolation and characterization of mollenynes B-E.
mollenynes
JACS paper

Posted in Alkynes, Computational, DFT, Halogenated, New Techniques, NMR, Peptides, Polyenes, Stereochemistry | Leave a Comment »

Forazoline A

Posted by naturalproductman on September 10, 2014

I thought I was going to have some down time before I posted again, but I ran into this interesting isolation paper of forazoline A that is worth a gander from Tim Bugni’s lab in the University of Wisconsin. They used a 15N-13C HMQC technique to determine which carbon was bonded to which nitrogen, which is apparently the first time this technique was used for a natural product. Looks like a pretty large natural product (m/z 901.4205). They have an interesting looking 13C NMR spectrum of the natural product (13C-labeled) that have splitting patterns on basically all of the carbons of the natural product (and thus looks like a proton NMR).

ACIE paper

Posted in Antifungal, New Setups, New Types, NMR, Polyketides, Polythio Compounds, Thiazoles | Leave a Comment »

ASAP HSQC

Posted by naturalproductman on January 20, 2014

Burkhard Luy and co-workers at Karlsruher Institut für Technologie in Germany have reported in JACS on a quick HSQC NMR method.
HSQC
JACS paper

Posted in New Setups, New Types, NMR | 1 Comment »