Naturalproductman’s Blog

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Archive for the ‘Peptides’ Category

Spiruchostatin A synthesis

Posted by naturalproductman on August 26, 2015

Takuyuki Doi and co-workers from Tohoku University have reported in Tetrahedron on a solid phase synthesis of spiruchostatin A.
spiruchostatin
Tetrahedron paper

Posted in Peptides, Total Synthesis | Leave a Comment »

Yaku’amide synthesis

Posted by naturalproductman on July 17, 2015

Masayuki Inoue and co-workers from the University of Tokyo have reported in JACS on the synthesis of yaku’amide.

peptide

JACS paper

Posted in Peptides, Structural Reassignment | Leave a Comment »

Nannocystin A

Posted by naturalproductman on July 17, 2015

Dominic Hoepfner and co-workers from Novartis have reported in ACIE on nannocystin A, which had similar binding properties with didemin B on EF-1alpha (elongation factor 1 inhibitor).

nannocystin A

ACIE paper

Mark Brönstrup and co-workers at Helmholtz Zentrum für Infektionsforschung also reported on the isolation of this small molecule. I wonder if there’s a relationship between the two studies.

ACIE paper

the novartis paper states that their study parallels the work in helmholtz. I guess the two studies just coincidentally resulted in the isolation of the same compound.

Posted in Biosynthesis, Cancer, Chemical Biology, Macrocycles, Macrolides, Peptides | Leave a Comment »

Staphyloferrin B synthesis

Posted by naturalproductman on July 11, 2015

Elizabeth Nolan and co-workers from MIT have reported in JACS on the synthesis of staphyloferrin B, an iron chelating natural product found in bacteria.

iron

JACS paper

Posted in Chemical Biology, Peptides, Total Synthesis | Leave a Comment »

Coprisamides A and B

Posted by naturalproductman on February 22, 2015

Dong-Chan Oh and co-workers from Seoul National University have reported in Organic Letters on the isolation of coprisamides A and B from gut bacteria of beetles.

coprisamides

OL paper

Posted in Peptides | Leave a Comment »

Jahanyne

Posted by naturalproductman on January 17, 2015

Kiyotake Suenaga and co-workers from Keio University have reported in Organic Letters on the isolation of jahanyne.

lipopeptide
OL paper

Posted in Apoptosis, Peptides | Leave a Comment »

Lysocin E synthesis

Posted by naturalproductman on December 15, 2014

Masayuki Inoue and co-workers have reported in ACIE on the synthesis of lysocin E.

peptide

ACIE paper

Posted in Peptides, Total Synthesis | Leave a Comment »

Mannopeptimycin aglycone synthesis

Posted by naturalproductman on August 18, 2014

Takayuki Doi and co-workers at Tohoku University have reported in JACS on the synthesis of mannopeptimycin aglycone.

mannopeptimycin aglycone

JACS paper

Posted in Aldol, Methodology, Peptides | Leave a Comment »

1-Alaninechlamydocin

Posted by naturalproductman on July 15, 2014

Robert Cichewicz and co-workers from the University of Oklahoma have reported in the Journal of Natural Products on the isolation of a tetrapeptide with HDAC inhibitory activity. This compound was isolated from a fungus in Lake Superior.

peptide

JNP paper

Posted in Cancer, Histone deacetylase, Peptides, Protein Targets | Leave a Comment »

Polyketide-peptide hybrid

Posted by naturalproductman on June 28, 2014

Liangcheng Du and co-workers at University of Nebraska-Lincoln have reported in ACIE on a polyketide synthase–nonribosomal peptide synthetase that made a hybrid polyketide-peptide compound.

polyketide

ACIE paper

Posted in Chemical Biology, Hybrids, Peptides, Polyketides | Leave a Comment »

 
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