Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Peptides’ Category

Vancomycin derivative

Posted by naturalproductman on May 29, 2016

Here’s a report on a vancomycin derivative with a pyrophosphate binding group reported by Jayanta Haldar and co-workers at Jawaharlal Nehru Centre for Advanced Scientific Research.

 

ACIE paper

Posted in Antibiotics, Peptides, Unnatural Products | Leave a Comment »

Precolibactin synthesis/structural revision

Posted by naturalproductman on March 31, 2016

Seth Herzon and co-workers from Yale have reported in JACS on the synthesis of precolibactin. It’s another example of why total synthesis is important. But another interesting aspect about this natural product is that previous efforts used bioinformatics approaches to propose the thiazoline-thiazole chain – when in fact the natural product has a terminal cysteine appended where this thiazoline-thiazole chain was proposed to exist.

 

JACS paper

Posted in Biosynthesis, Peptides, Structural Reassignment, Total Synthesis | Leave a Comment »

Biosynthetic origin of L-allo-isoleucine in desotamides and marformycins

Posted by naturalproductman on January 18, 2016

Jianhua Ju and co-workers at the Chinese Academy of Sciences have reported in JACS on the biosynthetic origin of L-allo-isoleucine. The culprit is a PLP-enzyme.

 

JACS paper

Posted in Biosynthesis, Enzymatic, Enzymes, Peptides | Leave a Comment »

Ustiloxin D synthesis

Posted by naturalproductman on October 28, 2015

Craig Hutton and co-workers from University of Melbourne have reported in JOC on a synthesis of ustiloxin using an ammonia-Ugi reaction.
Ugi

JOC paper

Posted in Multi-Component Coupling, Named Reactions, Peptides, Total Synthesis | Leave a Comment »

Marthiapeptide synthesis

Posted by naturalproductman on October 15, 2015

Shelli McAlpine and co-workers at the University of New South Wales have reported in Organic Letters on the synthesis of marthiapeptide.

peptide

OL paper

Posted in Peptides, Total Synthesis | Leave a Comment »

Coibamide A synthesis

Posted by naturalproductman on October 15, 2015

Wu Su and co-workers from the Chinese Academy of Sciences have reported in JACS on the synthesis of coibamide A.

peptide

JACS paper

Posted in Macrocycles, Peptides, Structural Reassignment, Total Synthesis | Leave a Comment »

Mollenynes B-E

Posted by naturalproductman on September 25, 2015

Tadeusz Molinski and co-workers have reported in JACS on the isolation and characterization of mollenynes B-E.
mollenynes
JACS paper

Posted in Alkynes, Computational, DFT, Halogenated, New Techniques, NMR, Peptides, Polyenes, Stereochemistry | Leave a Comment »

Spiruchostatin A synthesis

Posted by naturalproductman on August 26, 2015

Takuyuki Doi and co-workers from Tohoku University have reported in Tetrahedron on a solid phase synthesis of spiruchostatin A.
spiruchostatin
Tetrahedron paper

Posted in Peptides, Total Synthesis | Leave a Comment »

Yaku’amide synthesis

Posted by naturalproductman on July 17, 2015

Masayuki Inoue and co-workers from the University of Tokyo have reported in JACS on the synthesis of yaku’amide.

peptide

JACS paper

Posted in Peptides, Structural Reassignment | Leave a Comment »

Nannocystin A

Posted by naturalproductman on July 17, 2015

Dominic Hoepfner and co-workers from Novartis have reported in ACIE on nannocystin A, which had similar binding properties with didemin B on EF-1alpha (elongation factor 1 inhibitor).

nannocystin A

ACIE paper

Mark Brönstrup and co-workers at Helmholtz Zentrum für Infektionsforschung also reported on the isolation of this small molecule. I wonder if there’s a relationship between the two studies.

ACIE paper

the novartis paper states that their study parallels the work in helmholtz. I guess the two studies just coincidentally resulted in the isolation of the same compound.

Posted in Biosynthesis, Cancer, Chemical Biology, Macrocycles, Macrolides, Peptides | Leave a Comment »

 
Follow

Get every new post delivered to your Inbox.

Join 84 other followers