Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Polycyclic’ Category

Halichondrin

Posted by naturalproductman on October 7, 2009

When an expert in total synthesis such as Kishi has a name on a journal article that is focused on synthesis of natural products, you know it has to be good.  The highlight of this synthesis is really the Ni/Cr catalyzed coupling using an aldehyde and a vinyl iodide.

halichondrin

h2

JACS paper 1

JACS paper 2

Posted in Asymmetric, cross coupling, Macrolides, Methodology, Polycyclic, Polyether, Transition Metal | Leave a Comment »

Elisapterosin F

Posted by naturalproductman on August 17, 2009

Elisapterosin F has recently been isolated by Abimael Rodriguez and co-worker at the University of Puerto Rico.   Its structure says it all.  They didn’t isolate enough to test any biological activities but from the previously isolated elisapterosins (D and E), these structures have anti-plasmodial activity (10 microgams/mL).

elisapterosin F

TL paper

TL paper 2003 (Elisapterosins D and E)

Posted in Diterpene, Polycyclic | Leave a Comment »

Interesting Polycyclic Targets

Posted by naturalproductman on August 12, 2009

Ji-Jun Chen and et al from the Chinese Academy of Sciences have recently published in Organic Letters on the isolation of swerilactones A and B from the Chinese herb, Swertia mileensis.  This herb was traditionally used to treat the hepatitis B virus in the Yunnan province.  Swerilactone A possessed activity against HBsAg secretion with an IC50 value of 3.66 mM.

OL paperswerilactone

Posted in Lactones, Polycyclic | 1 Comment »