Posted by naturalproductman on October 7, 2009
When an expert in total synthesis such as Kishi has a name on a journal article that is focused on synthesis of natural products, you know it has to be good. The highlight of this synthesis is really the Ni/Cr catalyzed coupling using an aldehyde and a vinyl iodide.
Posted in Asymmetric, cross coupling, Macrolides, Methodology, Polycyclic, Polyether, Transition Metal | Leave a Comment »
Posted by naturalproductman on August 17, 2009
Elisapterosin F has recently been isolated by Abimael Rodriguez and co-worker at the University of Puerto Rico. Its structure says it all. They didn’t isolate enough to test any biological activities but from the previously isolated elisapterosins (D and E), these structures have anti-plasmodial activity (10 microgams/mL).
Posted in Diterpene, Polycyclic | Leave a Comment »
Posted by naturalproductman on August 12, 2009
Ji-Jun Chen and et al from the Chinese Academy of Sciences have recently published in Organic Letters on the isolation of swerilactones A and B from the Chinese herb, Swertia mileensis. This herb was traditionally used to treat the hepatitis B virus in the Yunnan province. Swerilactone A possessed activity against HBsAg secretion with an IC50 value of 3.66 mM.
Posted in Lactones, Polycyclic | 1 Comment »
