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Archive for the ‘Polyether’ Category

Polyepoxide Openings to Make Poly-tetrahydropyrans

Posted by naturalproductman on May 14, 2009

Timothy Jamison at MIT has been working on this poly-epoxide cascade opening for a while in order to make these polycyclic rings.

polyepoxide opening

ACIEE paper

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Posted in Cascade Reactions, Methodology, Polyether | Leave a Comment »

Synthesis of Brevenal

Posted by naturalproductman on May 14, 2009

Yoshinori Yamamoto at Tohoku University has recently published in Organic Letters on the synthesis of Brevenal. This polyether-polycyclic compound was synthesized in 57 steps in 0.84% overall yield. Wow – that’s a lot of steps.

brevenal

OL paper

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Protoceratins, Cytotoxic Polyether Natural Products from Dinoflagellates

Posted by naturalproductman on May 10, 2009

Yuzuru Shimizu from the University of Rhode Island published in 2004 in the Journal of Natural Products on the isolation of novel polyether natural products that possess sub nanomolar activity against human cancer cell lines.  They were dubbed protoceratins after they were isolated from dinoflagellates Protoceratium cf. reticulatum.

protoceratin

JNP paper

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Ciguatoxin

Posted by naturalproductman on March 18, 2009

Minoru Isobe from Nagoya University has reported the synthesis of ciguatoxin.  It’s a beast of a molecule and an outstanding achievement.
ciguatoxin

ACIEE paper

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Norhalichondrin B

Posted by naturalproductman on February 16, 2009

Andrew J. Philips at the University of Colorado in Boulder has just recently published in ACIEE a total synthesis of Norhalichondrin B.  The structure of the molecule explains itself.

norhalichondrin B

ACIEE paper

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