Naturalproductman’s Blog

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Archive for the ‘Polyketides’ Category

Rubriflordilactone A synthesis

Posted by naturalproductman on September 2, 2015

Edward Anderson and co-workers from the University of Oxford have reported in ACIE on the synthesis of rubriflordilactone A.

lactone

ACIE paper

Posted in Lactones, Polyketides, Total Synthesis | Leave a Comment »

Pericoannosin A

Posted by naturalproductman on August 27, 2015

Jungui Dai and co-workers from Chinese Academy of Medical Sciences have reported in Organic Letters on the isolation of pericoannosin A.

funal

OL paper

Posted in Antiviral, Polyketides | Leave a Comment »

Griseusin synthesis

Posted by naturalproductman on August 20, 2015

Jon Thorson and co-workers from the University of Kentucky have reported in ACIE on the syntheses of griseusins.
griseusins
ACIE paper

Posted in C-H activation, Methodology, Polyketides, Total Synthesis | Leave a Comment »

Molecular prosthetics

Posted by naturalproductman on August 7, 2015

Martin Burke’s group is making use of their small molecules that they’re synthesizing.
prosthetic
JACS paper

Posted in Chemical Biology, Macrolides, Methodology, Polyenes, Polyketides | Leave a Comment »

Towards naphthocyclinones

Posted by naturalproductman on July 1, 2015

Keisuke Suzuki and co-workers at the Tokyo Institute of Technology have reported in ACIE on their strategy towards Naphthocyclinones.

polyketide

ACIE paper

Posted in Antibiotics, Dimer, Polyketides | Leave a Comment »

Spirooliganone synthesis

Posted by naturalproductman on June 6, 2015

Shishan Yu and co-workers from the Chinese Academy of Sciences at have reported in Organic Letters on the synthesis of spirooliganone, which had 0.41 μM IC50 activity against Coxsackie virus B3.

spirooliganone
OL paper

Posted in Antiviral, Polyketides, Total Synthesis | Leave a Comment »

Towards halichondrins

Posted by naturalproductman on May 12, 2015

I would call the vinyl halide coupling reaction with an aldehyde using chromium/nickel combination a Nozaki Hiyama Kishi coupling, but maybe because the author is one of the people in the named reaction, it wasn’t mentioned in the paper as the “NHK reaction”, but rather, a Ni/Cr-mediated reaction.

halichondrin

JACS paper

JACS paper 2

Posted in Chromium, cross coupling, Methodology, Named Reactions, Nickel, Polyketides, Total Synthesis | Leave a Comment »

Santalin Y synthesis

Posted by naturalproductman on April 12, 2015

Dirk Trauner and co-workers have reported in ACIE on the synthesis of santalin Y.
santalin Y

ACIE paper

Posted in Cascade Reactions, Polyketides, Total Synthesis | Leave a Comment »

Resveratrol binds to human tyrosyl transfer-RNA (tRNA) synthetase

Posted by naturalproductman on March 21, 2015

Paul Schimmel and colleague at Scripps have reported in Nature on a resveratrol target. We all think of red wine when we hear resveratrol.

Nature paper

Posted in Aromatic, Polyketides, Protein Targets | Leave a Comment »

Kalkitoxin synthesis

Posted by naturalproductman on March 5, 2015

Varinder Aggarwal and co-workers from the University of Bristol have reported in JACS on the synthesis of kalkitoxin.
kalkitoxin
JACS paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

 
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