Naturalproductman’s Blog

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Archive for the ‘Polyketides’ Category

Santalin Y synthesis

Posted by naturalproductman on April 12, 2015

Dirk Trauner and co-workers have reported in ACIE on the synthesis of santalin Y.
santalin Y

ACIE paper

Posted in Cascade Reactions, Polyketides, Total Synthesis | Leave a Comment »

Resveratrol binds to human tyrosyl transfer-RNA (tRNA) synthetase

Posted by naturalproductman on March 21, 2015

Paul Schimmel and colleague at Scripps have reported in Nature on a resveratrol target. We all think of red wine when we hear resveratrol.

Nature paper

Posted in Aromatic, Polyketides, Protein Targets | Leave a Comment »

Kalkitoxin synthesis

Posted by naturalproductman on March 5, 2015

Varinder Aggarwal and co-workers from the University of Bristol have reported in JACS on the synthesis of kalkitoxin.
kalkitoxin
JACS paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Tetracycline analogs

Posted by naturalproductman on February 22, 2015

Hrvoje Petkovic and co-workers at University of Ljubljana have reported in ACIE on a biosynthetic engineering approach to produce new tetracycline compounds.

tetracycline

ACIE paper

Posted in Biosynthesis, Chemical Biology, Polyketides, Tetracycline | Leave a Comment »

Brazilin synthesis

Posted by naturalproductman on January 18, 2015

Ikyon Kim and colleague from Yonsei University have reported in JOC on the synthesis of brazilin.

brazilin

JOC paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Trioxacarcin DC-45-A2 synthesis

Posted by naturalproductman on January 17, 2015

KC Nicolaou and co-workers have reported in ACIE on the synthesis of trioxacarcin DC-45-A2. polyketide ACIE paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Aglaiastatin synthesis

Posted by naturalproductman on January 17, 2015

John Porco and co-workers have reported in JACS on the synthesis of aglaiastatin.
aglaiastatin
JACS paper

Posted in Asymmetric, Methodology, Polyketides, Total Synthesis | Leave a Comment »

Tiacumicin B (Lipiarmycin A3/Fidaxomicin) aglycone synthesis

Posted by naturalproductman on December 15, 2014

Karl Heinz-Altmann and co-workers at ETH Zurich have reported in ACIE on the synthesis of fidaxomicin aglycone.

fidaxomicin

ACIE paper

Posted in Macrolides, Polyenes, Polyketides, Total Synthesis | Leave a Comment »

Leucosceptroids A and B syntheses

Posted by naturalproductman on December 6, 2014

Dawei Ma and co-workers have reported in ACIE on the synthesis of leucosceptroids A and B.

A and B

ACIE paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Kushecarpin A synthesis

Posted by naturalproductman on December 6, 2014

Thomas Pettus and co-workers have reported in ACIE on the syntheses of some polyketides related to kushecarpin A.

kushecarpin A

ACIE paper

Posted in Polyketides, Total Synthesis, Unified | Leave a Comment »

 
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