Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Polyketides’ Category

Towards naphthocyclinones

Posted by naturalproductman on July 1, 2015

Keisuke Suzuki and co-workers at the Tokyo Institute of Technology have reported in ACIE on their strategy towards Naphthocyclinones.

polyketide

ACIE paper

Posted in Antibiotics, Dimer, Polyketides | Leave a Comment »

Spirooliganone synthesis

Posted by naturalproductman on June 6, 2015

Shishan Yu and co-workers from the Chinese Academy of Sciences at have reported in Organic Letters on the synthesis of spirooliganone, which had 0.41 μM IC50 activity against Coxsackie virus B3.

spirooliganone
OL paper

Posted in Antiviral, Polyketides, Total Synthesis | Leave a Comment »

Towards halichondrins

Posted by naturalproductman on May 12, 2015

I would call the vinyl halide coupling reaction with an aldehyde using chromium/nickel combination a Nozaki Hiyama Kishi coupling, but maybe because the author is one of the people in the named reaction, it wasn’t mentioned in the paper as the “NHK reaction”, but rather, a Ni/Cr-mediated reaction.

halichondrin

JACS paper

JACS paper 2

Posted in Chromium, cross coupling, Methodology, Named Reactions, Nickel, Polyketides, Total Synthesis | Leave a Comment »

Santalin Y synthesis

Posted by naturalproductman on April 12, 2015

Dirk Trauner and co-workers have reported in ACIE on the synthesis of santalin Y.
santalin Y

ACIE paper

Posted in Cascade Reactions, Polyketides, Total Synthesis | Leave a Comment »

Resveratrol binds to human tyrosyl transfer-RNA (tRNA) synthetase

Posted by naturalproductman on March 21, 2015

Paul Schimmel and colleague at Scripps have reported in Nature on a resveratrol target. We all think of red wine when we hear resveratrol.

Nature paper

Posted in Aromatic, Polyketides, Protein Targets | Leave a Comment »

Kalkitoxin synthesis

Posted by naturalproductman on March 5, 2015

Varinder Aggarwal and co-workers from the University of Bristol have reported in JACS on the synthesis of kalkitoxin.
kalkitoxin
JACS paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Tetracycline analogs

Posted by naturalproductman on February 22, 2015

Hrvoje Petkovic and co-workers at University of Ljubljana have reported in ACIE on a biosynthetic engineering approach to produce new tetracycline compounds.

tetracycline

ACIE paper

Posted in Biosynthesis, Chemical Biology, Polyketides, Tetracycline | Leave a Comment »

Brazilin synthesis

Posted by naturalproductman on January 18, 2015

Ikyon Kim and colleague from Yonsei University have reported in JOC on the synthesis of brazilin.

brazilin

JOC paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Trioxacarcin DC-45-A2 synthesis

Posted by naturalproductman on January 17, 2015

KC Nicolaou and co-workers have reported in ACIE on the synthesis of trioxacarcin DC-45-A2. polyketide ACIE paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Aglaiastatin synthesis

Posted by naturalproductman on January 17, 2015

John Porco and co-workers have reported in JACS on the synthesis of aglaiastatin.
aglaiastatin
JACS paper

Posted in Asymmetric, Methodology, Polyketides, Total Synthesis | Leave a Comment »

 
Follow

Get every new post delivered to your Inbox.

Join 81 other followers