Naturalproductman’s Blog

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Archive for the ‘Polyketides’ Category

Prymnesins

Posted by naturalproductman on August 23, 2016

Thomas Ostenfeld Larsen and co-workers at Technical University of Denmark reported in the isolation of B-type prymnesins from microalga. These look like the big brevetoxins.

 

JNP paper

Posted in Polyketides | Leave a Comment »

Juglorescein and Juglocombins A and B synthesis

Posted by naturalproductman on July 30, 2016

Kouji Kuramochi and co-workers from Tokyo University of Science have reported in ACIE on the synthesis of juglorescein.

 

ACIE paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Chiral Anion Phase Transfer (CAPT)

Posted by naturalproductman on July 30, 2016

Dean Toste and co-workers have reported in JACS on the enantioselective synthesis of flavonoids using CAPT.

 

JACS paper

Posted in Asymmetric, Polyketides, Total Synthesis | Leave a Comment »

Callyspongiolide synthesis

Posted by naturalproductman on May 29, 2016

Tao Ye and co-workers from Peking University have reported in JACS on the synthesis of callyspongiolide.

 

JACS paper

Posted in Alkynes, Macrolides, Polyketides, Total Synthesis | Leave a Comment »

From a trans to cis olefin and oxidations

Posted by naturalproductman on April 14, 2016

Kenji Watanabe and co-workers from the University of Shizuoka have reported in ACIE on an enzyme system (PsoE (glutathione S-transferase) and PsoF (flavin-containing monooxygenase)) that involves glutathione conjugation of a polyolefinic natural product (presynerazol) to form a glutathione adduct intermediate, which in turn is oxidized to the sulfoxide (by flavin hydroperoxide) and eliminates to form a cis-olefin (synerazol).

 

ACIE paper

Posted in Biosynthesis, Polyketides | Leave a Comment »

ent-Ascospiroketals A and B syntheses

Posted by naturalproductman on April 7, 2016

Rongbiao Tong and colleague from Hong Kong University of Science and Technology have reported in Organic Letters on the synthesis of ascospiroketals A and B.

 

OL paper

Posted in Cascade Reactions, Polyketides, Total Synthesis | Leave a Comment »

Helicascolide syntheses

Posted by naturalproductman on April 5, 2016

Bernhard Breit and co-workers from Albert-Ludwigs-Universität Freiburg have reported in ACIE on the synthesis of helicascolides A, B, and C.

 

ACIE paper

Posted in Methodology, Polyketides, Total Synthesis | Leave a Comment »

Trioxacarcins syntheses

Posted by naturalproductman on February 24, 2016

KC Nicolaou and co-workers reported in JACS on the synthesis of trioxacarcins. The abstract figure looks interstellar.

 

JACS paper

 

 

Posted in Polyketides, Total Synthesis | Leave a Comment »

Hippolachnin A synthesis

Posted by naturalproductman on February 12, 2016

Kevin Brown (Indiana University) and John Wood (Baylor University) and co-workers have reported in JACS on the synthesis of hippolachnin A.

 

JACS paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

A natural product binding protein

Posted by naturalproductman on February 12, 2016

Using NMR, David Jakeman and co-workers at Dalhousie University reported in JACS on a natural product binding protein, JadX.

 

JACS paper

Posted in New Techniques, NMR, Polyketides | Leave a Comment »

 
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