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Archive for the ‘Polyspirocyclic’ Category

Anti-Malarial Natural Product Leads to More Potent Structures

Posted by naturalproductman on May 9, 2009

Aculeatin, a polyspirocyclic natural product isolated from the rhizome, Amomun aculeatum, which is a plant that is used to treat malaria and fever in Papua, New Guinea, was isolated in 2000 and reported in Helv. Chim. Acta. by Heilman and co-workers (HCA link).  Yung-Sing Wong and co-workers from Universite de Grenoble in France has published in Jounral of Medicinal Chemistry on some active analogues of this natural product in 2008 – with nanomolar activity against the protist, Plasmodium falciporum, which is responsible for malaria.

aculeatin analogues

JMC link

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