I thought I was going to have some down time before I posted again, but I ran into this interesting isolation paper of forazoline A that is worth a gander from Tim Bugni’s lab in the University of Wisconsin. They used a 15N-13C HMQC technique to determine which carbon was bonded to which nitrogen, which is apparently the first time this technique was used for a natural product. Looks like a pretty large natural product (m/z 901.4205). They have an interesting looking 13C NMR spectrum of the natural product (13C-labeled) that have splitting patterns on basically all of the carbons of the natural product (and thus looks like a proton NMR).
Archive for the ‘Polythio Compounds’ Category
Posted by naturalproductman on September 10, 2014
Posted by naturalproductman on August 20, 2014
Cui-Xian Zhang and co-workers from Guangzhou University have reported in Tetrahedron on a poly-sulfur lactone compound.
Posted by naturalproductman on March 1, 2013
Larry Overman and co-workers have reported in JACS on some syntheses of gliocladin C and some other dithio alkaloids.
Posted by naturalproductman on November 19, 2012
Hidetoshi Tokuyama and co-workers at Tohoku University have published in ACIE on the synthesis of acetylaranotin.
Posted by naturalproductman on October 25, 2011
Jon Clardy and co-workers at Harvard have reported in JACS on some new molecules isolated from bacteria.
Posted by naturalproductman on October 14, 2011
Yi-Qiang Cheng and co-workers from the University of Wisconsin in Milwaukee have reported in the Journal of Natural Products on some disulfide compounds that have HDAC inhibitory activity – the compounds with the reduced disulfide bond was shown to be more active than the oxidized dithiol form.
Posted by naturalproductman on June 6, 2011
Frank Schroeder and co-workers at Cornell have reported in JACS on the isolation of gli dependent metabolites using differential analysis by 2D NMR spectroscopy (DANS).
Posted by naturalproductman on May 12, 2011
Nicolaou and co-workers have reported in JACS on their total synthesis of epicoccin G using a Kornblum-DeLaMare rearrangement to access the gamma-hydroxy ketone.
Posted by naturalproductman on November 5, 2010
Hendrik Luesch and co-workers from the University of Florida have published in JOC on the isolation and biological activities of grassypeptolides. Grassypeptolide C had 44.6 nM IC50 against HeLa cells.