Naturalproductman’s Blog

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Archive for the ‘Protein Targets’ Category

Simmonosides A and B

Posted by naturalproductman on April 4, 2016

Xueting Liu and co-workers from the Chinese Academy of Sciences have reported in Organic Letters on some cyclobutane containing natural products isolated from aqueous extracts of jojoba leaves.

 

OL paper

Posted in Anti-inflammatory, COX-2 (cyclooxygenase-2), Cyclobutanes | Leave a Comment »

Nahuoic acid

Posted by naturalproductman on February 3, 2016

Raymond Andersen and co-workers reported in JOC on the isolation of nahuoic acid. They used Rychnovsky’s method to determine the relative stereochemistry of the alcohols.

 

JOC paper

Posted in Cancer, Classic papers, Classical rules, Polyketides, Protein Targets, Rycnovsky's rules | Leave a Comment »

Halicylindramides

Posted by naturalproductman on February 2, 2016

Heonjoong Kang and co-workers from Seoul National University have reported in the Journal of Natural Products on the isolation of halicylindramides (FXR antagonists).

 

JNP paper

Posted in Cancer, Depsipeptides, Protein Targets | Leave a Comment »

MAP4K4 for neurodegenerative diseases

Posted by naturalproductman on April 26, 2015

Herbert Waldmann and co-workers at Technische Universität Dortmund have reported in ACIE on MAP4K4 as a target for neurodegenerative diseases.

MAP

ACIE paper

Posted in Diseases, Medicinal Chemistry, Neurodegenerative, Protein Targets, Proteins | Leave a Comment »

Resveratrol binds to human tyrosyl transfer-RNA (tRNA) synthetase

Posted by naturalproductman on March 21, 2015

Paul Schimmel and colleague at Scripps have reported in Nature on a resveratrol target. We all think of red wine when we hear resveratrol.

Nature paper

Posted in Aromatic, Polyketides, Protein Targets | Leave a Comment »

Englerin A activates TRPC4 and TRPC5

Posted by naturalproductman on February 23, 2015

Herbert Waldmann and co-workers at Max-Planck-Institut fur Molekulare Physiologie have reported in ACIE on the target of englerin A. This report is very interesting. When I think of TRPC channels (Transient receptor potential canonical channels), I usually think of our taste buds and how the different electrophiles activate different tastes (bitterness, etc). I guess this calcium influx kills the cancer cells according to the authors. And some how this is all happening selectively for renal cancer cells and not the other kind of cancer cells.
englerin A

ACIE paper

Posted in Chemical Biology, Protein Targets, Sesquiterpenes | Leave a Comment »

Dibefurin synthesis

Posted by naturalproductman on November 8, 2014

Dirk Trauner and co-workers have reported in ACIE on the synthesis of dibefurin.

dibefurin

ACIE paper

Posted in Protein Targets, Total Synthesis | Leave a Comment »

Leiodermatolide synthesis

Posted by naturalproductman on October 28, 2014

Furstner and colleagues have reported in JACS on the synthesis of leiodermatolide.

leiodermatolide

JACS paper

Posted in Cancer, P-glycoprotein, Protein Targets, Total Synthesis | Leave a Comment »

Amdigenols E and G

Posted by naturalproductman on October 25, 2014

Toshiyasu Inuzuka and co-workers from Gifu University have reported in Tetrahedron Letters on the isolation of amdigenols E and G from dinoflagellates, and they had activity against N-type Ca2+ channel opening.
amdigenols E and G

TL paper

Posted in Polyketides, Protein Targets | Leave a Comment »

1-Alaninechlamydocin

Posted by naturalproductman on July 15, 2014

Robert Cichewicz and co-workers from the University of Oklahoma have reported in the Journal of Natural Products on the isolation of a tetrapeptide with HDAC inhibitory activity. This compound was isolated from a fungus in Lake Superior.

peptide

JNP paper

Posted in Cancer, Histone deacetylase, Peptides, Protein Targets | Leave a Comment »

 
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