Naturalproductman’s Blog

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Archive for the ‘Protein Targets’ Category

MAP4K4 for neurodegenerative diseases

Posted by naturalproductman on April 26, 2015

Herbert Waldmann and co-workers at Technische Universität Dortmund have reported in ACIE on MAP4K4 as a target for neurodegenerative diseases.

MAP

ACIE paper

Posted in Diseases, Medicinal Chemistry, Neurodegenerative, Protein Targets, Proteins | Leave a Comment »

Resveratrol binds to human tyrosyl transfer-RNA (tRNA) synthetase

Posted by naturalproductman on March 21, 2015

Paul Schimmel and colleague at Scripps have reported in Nature on a resveratrol target. We all think of red wine when we hear resveratrol.

Nature paper

Posted in Aromatic, Polyketides, Protein Targets | Leave a Comment »

Englerin A activates TRPC4 and TRPC5

Posted by naturalproductman on February 23, 2015

Herbert Waldmann and co-workers at Max-Planck-Institut fur Molekulare Physiologie have reported in ACIE on the target of englerin A. This report is very interesting. When I think of TRPC channels (Transient receptor potential canonical channels), I usually think of our taste buds and how the different electrophiles activate different tastes (bitterness, etc). I guess this calcium influx kills the cancer cells according to the authors. And some how this is all happening selectively for renal cancer cells and not the other kind of cancer cells.
englerin A

ACIE paper

Posted in Chemical Biology, Protein Targets, Sesquiterpenes | Leave a Comment »

Dibefurin synthesis

Posted by naturalproductman on November 8, 2014

Dirk Trauner and co-workers have reported in ACIE on the synthesis of dibefurin.

dibefurin

ACIE paper

Posted in Protein Targets, Total Synthesis | Leave a Comment »

Leiodermatolide synthesis

Posted by naturalproductman on October 28, 2014

Furstner and colleagues have reported in JACS on the synthesis of leiodermatolide.

leiodermatolide

JACS paper

Posted in Cancer, P-glycoprotein, Protein Targets, Total Synthesis | Leave a Comment »

Amdigenols E and G

Posted by naturalproductman on October 25, 2014

Toshiyasu Inuzuka and co-workers from Gifu University have reported in Tetrahedron Letters on the isolation of amdigenols E and G from dinoflagellates, and they had activity against N-type Ca2+ channel opening.
amdigenols E and G

TL paper

Posted in Polyketides, Protein Targets | Leave a Comment »

1-Alaninechlamydocin

Posted by naturalproductman on July 15, 2014

Robert Cichewicz and co-workers from the University of Oklahoma have reported in the Journal of Natural Products on the isolation of a tetrapeptide with HDAC inhibitory activity. This compound was isolated from a fungus in Lake Superior.

peptide

JNP paper

Posted in Cancer, Histone deacetylase, Peptides, Protein Targets | Leave a Comment »

So they made the trophy target, now what?

Posted by naturalproductman on May 29, 2014

Did you ever wonder what happened to palau’amine after they synthesized it? Was it the end of the story there? Well they did publish in the Journal of Natural Products in 2012 on the target of palau’amine and it was an inhibitor for the human 20S proteasome. You may wonder what the proteasome does:  it just degrades proteins (broken down or not needed) through proteolysis. Is that exciting? Well that may be a subjective question. It may be like saying is Coke delicious?

 

JNP paper

 

Posted in Alkaloids, Chemical Biology, Elucidation of natural product bioactivity, Protein Targets | Leave a Comment »

Swinhoeisterol

Posted by naturalproductman on April 3, 2014

Wen Zhang and co-workers from Second Military Medical University in China have reported in Organic Letters on the isolation of swinhoeisterol.
swinhoeisterol

OL paper

Posted in Protein Targets, Seven-Membered Rings, Steroids | Leave a Comment »

Bcl-XL and Bcl-2 interaction

Posted by naturalproductman on April 5, 2013

Thorsten Berg and co-workers at the University of Leipzig have reported in ACIE on the study of some small molecules disrupting the interaction of Bcl-XL and Bcl-2.

apoptosis

ACIE paper

Posted in Protein Targets, Proteins, Receptors | Leave a Comment »

 
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