Paul Schimmel and colleague at Scripps have reported in Nature on a resveratrol target. We all think of red wine when we hear resveratrol.
Archive for the ‘Protein Targets’ Category
Posted by naturalproductman on March 21, 2015
Posted by naturalproductman on February 23, 2015
Herbert Waldmann and co-workers at Max-Planck-Institut fur Molekulare Physiologie have reported in ACIE on the target of englerin A. This report is very interesting. When I think of TRPC channels (Transient receptor potential canonical channels), I usually think of our taste buds and how the different electrophiles activate different tastes (bitterness, etc). I guess this calcium influx kills the cancer cells according to the authors. And some how this is all happening selectively for renal cancer cells and not the other kind of cancer cells.
Posted by naturalproductman on November 8, 2014
Dirk Trauner and co-workers have reported in ACIE on the synthesis of dibefurin.
Posted by naturalproductman on October 28, 2014
Furstner and colleagues have reported in JACS on the synthesis of leiodermatolide.
Posted by naturalproductman on October 25, 2014
Toshiyasu Inuzuka and co-workers from Gifu University have reported in Tetrahedron Letters on the isolation of amdigenols E and G from dinoflagellates, and they had activity against N-type Ca2+ channel opening.
Posted by naturalproductman on July 15, 2014
Robert Cichewicz and co-workers from the University of Oklahoma have reported in the Journal of Natural Products on the isolation of a tetrapeptide with HDAC inhibitory activity. This compound was isolated from a fungus in Lake Superior.
Posted by naturalproductman on May 29, 2014
Did you ever wonder what happened to palau’amine after they synthesized it? Was it the end of the story there? Well they did publish in the Journal of Natural Products in 2012 on the target of palau’amine and it was an inhibitor for the human 20S proteasome. You may wonder what the proteasome does: it just degrades proteins (broken down or not needed) through proteolysis. Is that exciting? Well that may be a subjective question. It may be like saying is Coke delicious?
Posted by naturalproductman on April 3, 2014
Wen Zhang and co-workers from Second Military Medical University in China have reported in Organic Letters on the isolation of swinhoeisterol.
Posted by naturalproductman on April 5, 2013
Thorsten Berg and co-workers at the University of Leipzig have reported in ACIE on the study of some small molecules disrupting the interaction of Bcl-XL and Bcl-2.
Posted by naturalproductman on February 22, 2013
Hayamitsu Adachi and co-workers from BIKAKEN have reported in JNP on a novel VEGF receptor tyrosine kinase inhibitor from bacteria. The only problem I see with this compound – from a toxicologist’s perspective – is that this is a quinone, and thus a very reactive electrophile. If this kind of functional group is used as a drug, who knows what other things it will react with in the body – be it DNA, proteins, etc…