Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Random’ Category

Article view metrics

Posted by naturalproductman on September 13, 2016

I noticed a new statistic on JACS papers. It has an “Article View Metrics” feature on the right hand side when you click on the abstract of any JACS article.

What is interesting is to notice the popularity of the type of chemistry based on the field: e.g. total synthesis, reaction methodology, enzyme mechanism, mass spectrometry techniques, etc.

My observation is that the synthetic organic chemistry field seems to be popular with more article views on that research area. I wonder if it’s because the regular JACS audience comprise more people from that research focus.

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Regarding Reproducibility

Posted by naturalproductman on September 6, 2016

Bob Bergman and Rick Danheiser have published an article on steps to enhance reproducibility in chemical research. One approach is to take a co-worker who has no experience in the new chemical reaction reported, and have them repeat the experiment based on the supporting information alone.

 

ACIE paper

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Writing in Chemistry – Woodward as an example

Posted by naturalproductman on July 4, 2016

Jeffrey Seeman from the University of Richmond reported in ACIE on the writing style of Woodward. I like what it says in the end of the account: “if only more chemists can relate their work as well, using their own language and style” – meaning don’t try to be a copycat version of Woodward, but instead be as good of a writer in your own way.

 

ACIE paper

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Good mentoring

Posted by naturalproductman on May 23, 2016

Here’s a document listing how to be a good mentor/mentee. Things I got out of it: good mentees respect the time of mentors so always come prepared before approaching your mentor.

Mentoring

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The importance of mentoring

Posted by naturalproductman on March 31, 2016

Here’s a nice article about mentoring.

 

Cell article

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Journal of Irreproducibility

Posted by naturalproductman on March 7, 2016

There’s a new journal on irreproducible results. I guess this used to be a joke but now it’s real.

I wonder if they will have some organic synthesis journal articles here as we know about some cases of irreproducible chemical reactions.

Science introduction

Preclinical Reproducibility and Robustness

Posted in Ethics, Random | Leave a Comment »

ONOO-

Posted by naturalproductman on March 4, 2016

The abstract figure is funny in this one – there is a diazenium-1,2-diol functional group in the synthesized compound that comes from “ONOO-“, which was highlighted in yellow and in my head, read as: “Oh Noo!!”

OL paper

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Why natural products are important (an update)

Posted by naturalproductman on February 9, 2016

Remember that natural products review by David Newman and Gordon Cragg from the NIH?

 

Here is an updated (2016) one covering new chemical entities, antibacterial, antifungal, antiviral, anticancer, antiparasitic, and anticancer from 1981 to 2014:

 

JNP paper

Posted in Cancer, Random, Unnatural Products | Leave a Comment »

Nuphar alkaloid chemical biology

Posted by naturalproductman on February 8, 2016

Jimmy Wu and co-workers reported in ACIE on the formal synthesis of nuphar alkaloids and their apoptotic activity. Did you know that the second “p” in “apoptosis” is silent and it is pronounced “apa-tosis”? The Greek word “apoptosis” means “falling off” or “dropping off” of flower petals or tree leaves.

 

ACIE paper

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A review of total synthesis and prospects for the future

Posted by naturalproductman on February 3, 2016

Larry Overman and co-workers have reported in ACIE on a nice review of 12 elegant examples of total synthesis of natural products bearing 2 or more quaternary carbon centers bonded to each other. I like that it is a nice “cliff notes” version of a lot of great work.

 

ACIE paper

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