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Archive for the ‘Steroids’ Category

First paper published

Posted by naturalproductman on November 6, 2017

Francis Yoshimoto and co-workers at the University of Texas at San Antonio report in the journal, Steroids, on the synthesis of a neurosteroid produced in the brains, 7alpha-hydroxypregnenolone, through an allylic C7-oxidation reaction. The oxidation was performed through either a C7-oxidation through CrO3 in the presence of 3,5-dimethylpyrazole followed by a stereoselective reduction or a regioselective and stereoselective allylic benzoyloxylation using CuBr and tert-butylperoxy benzoate.

STEROIDS FKY

Steroids paper

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Posted in C-H activation, Stereochemistry, Steroids, Total Synthesis | Leave a Comment »

Syntheses of 19-hydroxysarmentogenin and trewianin aglycone

Posted by naturalproductman on May 29, 2016

Pavel Nagorny and co-workers reported in JACS on the synthesis of 19-hydroxysarmentogenin and trewianin aglycone.

JACS paper

Posted in Steroids, Total Synthesis | Leave a Comment »

Steroid C12-hydroxylation published in JACS

Posted by naturalproductman on October 22, 2015

Phil Baran and co-workers reported in JACS on a copper catalyzed C12-hydroxylation reaction.
C12
 

 

JACS paper

Posted in C-H activation, Copper, Methodology, Steroids, Transition Metal | Leave a Comment »

Celastrol synthesis

Posted by naturalproductman on September 11, 2015

Dionicio Siegel and co-workers at UCSD have reported in JACS on the synthesis of celstrol.

celastroid

JACS paper

Posted in Cascade Reactions, Methodology, Steroids, Total Synthesis, Triterpenoids | Leave a Comment »

Mycoleptodiscin A synthesis

Posted by naturalproductman on April 26, 2015

Ang Li and co-workers from SIOC have reported in ACIE on the synthesis of mycoleptodiscin A.

mycoleptodiscin
ACIE paper

Posted in Alkaloids, Steroids, Total Synthesis | Leave a Comment »

Ouabagenin synthesis

Posted by naturalproductman on April 17, 2015

Masayuki Inoue and co-workers from the University of Tokyo have reported in Chemical Science on the synthesis of ouabagenin.

 
ouabagenin
Chemical Science paper

Posted in Steroids, Total Synthesis | Leave a Comment »

Solanioic acid

Posted by naturalproductman on April 12, 2015

Raymond Anderson and co-workers from the University of British Columbia have reported in Organic Letters on the isolation of solanioic acid.
solanoic acid
OL paper

Posted in Steroids | Leave a Comment »

Cucurbitacins make wild cucumbers bitter

Posted by naturalproductman on November 27, 2014

Yi Shang and co-workers at the Chinese Academy of Agricultural Sciences have reported in Science on the genes that make cucmbers bitter and the selection process that made domestic cucumbers not bitter – it had to do with the transcription factor called Bitter fruit.

Science paper

Posted in Food, Steroids | Leave a Comment »

Plakinamines N and O

Posted by naturalproductman on November 4, 2014

Kirk Gustafson and co-workers from the NCI have reported in JNP on the isolation of plakinamines N and O.
plakinamine

JNP paper

Posted in Alkaloids, Cancer, colon, Steroids | Leave a Comment »

Swinhoeisterol

Posted by naturalproductman on April 3, 2014

Wen Zhang and co-workers from Second Military Medical University in China have reported in Organic Letters on the isolation of swinhoeisterol.
swinhoeisterol

OL paper

Posted in Protein Targets, Seven-Membered Rings, Steroids | Leave a Comment »