Archive for the ‘Structural Reassignment’ Category
Posted by naturalproductman on November 24, 2015
Posted by naturalproductman on October 15, 2015
Wu Su and co-workers from the Chinese Academy of Sciences have reported in JACS on the synthesis of coibamide A.
Posted by naturalproductman on August 21, 2015
Karl Hale and colleague at the Queen’s University Belfast have reported in Organic Letters on the synthesis of mycothiazole.
Posted by naturalproductman on July 17, 2015
Masayuki Inoue and co-workers from the University of Tokyo have reported in JACS on the synthesis of yaku’amide.
Posted by naturalproductman on May 4, 2015
Armen Zakarian and co-workers have reported in JACS on the synthesis of muironolide A.
Posted by naturalproductman on April 16, 2015
Jeroen Disckschat and co-workers at Rheinische Friedrich-Wilhelms-Universität Bonn have reported in ACIE on a 13C-13C COSY method to elucidate the structure of hypodoratoxide.
Posted by naturalproductman on April 12, 2015
Rongbiao Tong and colleague from the Hong Kong University of Science and Technology have reported in Organic Letters on the synthesis of uprolide F diacetate.
Posted by naturalproductman on November 16, 2014
Rosario Hernández-Galán and co-workers at Universidad de Cádiz in Spain have reported in JOC on the synthesis of cinbotolide and the revised structure through total synthesis looks completely different from the proposed macrocyclic structure.
Posted by naturalproductman on October 11, 2014
Hidetoshi Tokuyama and co-workers from Tohoku University have reported in ACIE on the synthesis of haouamine B pentaacetate.
Posted by naturalproductman on May 22, 2014
Here’s a great example that was highlighted in C&E News illustrating why it is good to know chemistry and why people who are careful chemists/scientists are so valuable. The El-Deiry lab at Penn State had patented a compound they discovered with anti-cancer activity. Then the Janda group in Scripps had synthesized the structure and found it did not have the biological activity that was reported, and then they received the compound from NCI and it did have activity. The original structural assignment was incorrect as shown by X-ray crystallography. Now there’s a big issue.