Naturalproductman’s Blog

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Archive for the ‘Structural Reassignment’ Category

Cannabimovone synthesis

Posted by naturalproductman on May 29, 2016

Antonio Echavarran and co-workers from ICIQ have reported in ACIE on the synthesis of cannabimovone.

 

ACIE paper

Posted in alkyne, Cascade Reactions, Gold, Methodology, Structural Reassignment, Total Synthesis | Leave a Comment »

Precolibactin synthesis/structural revision

Posted by naturalproductman on March 31, 2016

Seth Herzon and co-workers from Yale have reported in JACS on the synthesis of precolibactin. It’s another example of why total synthesis is important. But another interesting aspect about this natural product is that previous efforts used bioinformatics approaches to propose the thiazoline-thiazole chain – when in fact the natural product has a terminal cysteine appended where this thiazoline-thiazole chain was proposed to exist.

 

JACS paper

Posted in Biosynthesis, Peptides, Structural Reassignment, Total Synthesis | Leave a Comment »

ACIE Journals of Interest 11/24/2015

Posted by naturalproductman on November 24, 2015

Hao Xu’s lab in University of Georgia have reported on an iron-catalyzed diazidation of olefins.

Dorian Didier’s lab from LMU Munich reported on an interesting one-pot reaction.

Xiaoguang Lei’s lab from Peking University reported on the structural revision of aspergillomarasmine A.

Kilian Muniz’s lab from ICIQ reported on a hypervalent iodine approach to form 1,2-diacetates from olefins, asymmetrically.

NATURALPRODUCTMAN11.24.2015

Posted in Cascade Reactions, Hypervalent Iodine, Methodology, Structural Reassignment, Total Synthesis | Leave a Comment »

Coibamide A synthesis

Posted by naturalproductman on October 15, 2015

Wu Su and co-workers from the Chinese Academy of Sciences have reported in JACS on the synthesis of coibamide A.

peptide

JACS paper

Posted in Macrocycles, Peptides, Structural Reassignment, Total Synthesis | Leave a Comment »

Mycothiazole synthesis

Posted by naturalproductman on August 21, 2015

Karl Hale and colleague at the Queen’s University Belfast have reported in Organic Letters on the synthesis of mycothiazole.

mycothiazole

OL paper

Posted in Alkaloids, Methodology, Structural Reassignment, Thiazoles, Total Synthesis | Leave a Comment »

Yaku’amide synthesis

Posted by naturalproductman on July 17, 2015

Masayuki Inoue and co-workers from the University of Tokyo have reported in JACS on the synthesis of yaku’amide.

peptide

JACS paper

Posted in Peptides, Structural Reassignment | Leave a Comment »

Muironolide A synthesis

Posted by naturalproductman on May 4, 2015

Armen Zakarian and co-workers have reported in JACS on the synthesis of muironolide A.

muironolide A

JACS paper

Posted in Macrolides, Structural Reassignment, Total Synthesis | Leave a Comment »

Hypodoratoxide structural revision through 13C-13C COSY

Posted by naturalproductman on April 16, 2015

Jeroen Disckschat and co-workers at Rheinische Friedrich-Wilhelms-Universität Bonn have reported in ACIE on a 13C-13C COSY method to elucidate the structure of hypodoratoxide.
structure

ACIE paper

Posted in Methodology, New Setups, Structural Reassignment | Leave a Comment »

Uprolide F diacetate

Posted by naturalproductman on April 12, 2015

Rongbiao Tong and colleague from the Hong Kong University of Science and Technology have reported in Organic Letters on the synthesis of uprolide F diacetate.
uprolide

OL paper

Posted in Structural Reassignment, Total Synthesis | Leave a Comment »

Structure revision through total synthesis

Posted by naturalproductman on November 16, 2014

Rosario Hernández-Galán and co-workers at Universidad de Cádiz in Spain have reported in JOC on the synthesis of cinbotolide and the revised structure through total synthesis looks completely different from the proposed macrocyclic structure.

cinbotolide

JOC paper

Posted in Structural Reassignment, Total Synthesis | Leave a Comment »